Activation of chicken bone marrow-derived dendritic cells induced by a Salmonella Enteritidis ghost vaccine candidate

被引：13
作者：
Kamble, N. M. [1 ,2 ]
Jawale, C. V. [1 ,2 ]
Lee, J. H. [1 ,2 ]
机构：
[1] Chonbuk Natl Univ, Dept Bioact Mat Sci, Coll Vet Med, Iksan Campus 570752, South Korea
[2] Chonbuk Natl Univ, Dept Vet Publ Hlth, Coll Vet Med, Iksan Campus 570752, South Korea
来源：
POULTRY SCIENCE | 2016年 / 95卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
Salmonella Enteritidis; ghost vaccine; chicken dendritic cell; cytokine; immune response; ENTERICA SEROVAR TYPHIMURIUM; ANTIGEN PRESENTATION; BACTERIAL GHOSTS; T-CELLS; INFECTION; MATURATION; GENERATION; CHALLENGE; RECEPTORS; PATTERNS;
D O I：
10.3382/ps/pew158
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Bacterial Ghost-based vaccine development has been applied to a variety of gram-negative bacteria. Developed Salmonella Enteritidis (S. Enteritidis) ghost are promising vaccine candidates because of their immunogenic and enhanced biosafety potential. In this study, we aimed to evaluate the immunostimulatory effect of a S. Enteritidis ghost vaccine on the maturation of chicken bone marrow-derived dendritic cells (chBM-DCs) in vitro. The immature chBM-DCs were stimulated with S. Enteritidis ghost vaccine candidate. The vaccine efficiently stimulated maturation events in chBM-DCs, indicated by up-regulated expression of CD40, CD80, and MHC-II molecules. Immature BM-DCs responded to stimulation with S. Enteritidis ghost by increased expression of IL-6 and IL-12p40 cytokines. Also, S. Enteritidis ghost stimulated chBM-DCs induced the significant expression of IFN-gamma and IL-2 in co-cultured autologous CD4+ T cells. In conclusion, our data suggest that S. Enteritidis ghost vaccine candidate is capable of activating and interacting with chBM-DCs. The results from current study may help for rational designing of Salmonella ghost based heterologous antigen delivery platforms to dendritic cells.
引用
收藏
页码：2274 / 2280
页数：7
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