New insight into calcinosis of juvenile dermatomyositis: A study of composition and treatment

被引:92
作者
Mukamel, M
Horev, G
Mimouni, M
机构
[1] Schneider Childrens Med Ctr Israel, Pediat Rheumatol Unit, IL-49202 Petah Tiqwa, Israel
[2] Schneider Childrens Med Ctr Israel, Pediat Imaging Dept, IL-49202 Petah Tiqwa, Israel
[3] Schneider Childrens Med Ctr Israel, Day Care Unit, IL-49202 Petah Tiqwa, Israel
[4] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
关键词
D O I
10.1067/mpd.2001.112473
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Milk of calcium developed in 2 children with juvenile dermatomyositis. The fluid of the collection contained macrophages, interleukin-6, IL-I, and tumor necrosis factor. The patient who had dystrophic calcinosis had a dramatic improvement with the introduction of alendronate. These findings suggest that calcinosis of juvenile dermatomyositis may be mediated by activated macrophages and that alendronate can be an effective treatment for this condition.
引用
收藏
页码:763 / 766
页数:4
相关论文
共 22 条
[1]  
ANSELL BM, 1991, RHEUM DIS CLIN N AM, V17, P931
[2]   MYOSITIS-OSSIFICANS PROGRESSIVA - A 10-YEAR FOLLOW-UP ON A PATIENT TREATED WITH ETIDRONATE DISODIUM [J].
BAROZ, B ;
BONEH, A .
ACTA PAEDIATRICA, 1994, 83 (12) :1332-1334
[3]  
Cimaz R, 1999, ARTHRITIS RHEUM, V42, pS400
[4]  
Ebrahimpour Arman, 1995, P125
[5]   HETEROTOPIC OSSIFICATION FOLLOWING HIP-REPLACEMENT OR SPINAL-CORD INJURY - 2 CLINICAL-STUDIES WITH EHDP [J].
FINERMAN, GAM ;
STOVER, SL .
METABOLIC BONE DISEASE & RELATED RESEARCH, 1981, 3 (4-5) :337-342
[6]   Bisphosphonates: Mechanisms of action [J].
Fleisch, H .
ENDOCRINE REVIEWS, 1998, 19 (01) :80-100
[7]  
GELDER JM, 1997, J PHARM SCI, V86, P283
[8]  
Giuliani N, 1998, SCAND J RHEUMATOL, V27, P38
[9]   MILK OF CALCIUM FLUID COLLECTION IN DERMATOMYOSITIS - ULTRASOUND FINDINGS [J].
HESLA, RB ;
KARLSON, LK ;
MCCAULEY, RGK .
PEDIATRIC RADIOLOGY, 1990, 20 (05) :344-346
[10]  
ISHIMI Y, 1990, J IMMUNOL, V145, P3297