Perihematomal Edema After Intracerebral Hemorrhage: An Update on Pathogenesis, Risk Factors, and Therapeutic Advances

被引：133
作者：
Chen, Yihao [1 ]
Chen, Shengpan [2 ]
Chang, Jianbo [1 ]
Wei, Junji [1 ]
Feng, Ming [1 ]
Wang, Renzhi [1 ]
机构：
[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Neurosurg, Beijing, Peoples R China
[2] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Inst Neurosci, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
intracerebral hemorrhage; perihematomal edema; neuroinflammation; pathophysiology; therapies; TRAUMATIC BRAIN-INJURY; INITIAL CONSERVATIVE TREATMENT; BLOOD-PRESSURE REDUCTION; ACTIVATED-RECEPTOR-GAMMA; FOCAL CEREBRAL-ISCHEMIA; PERIHEMORRHAGIC EDEMA; HEMATOMA EXPANSION; NATURAL-HISTORY; TIME-COURSE; MOLECULAR PATHOPHYSIOLOGY;
D O I：
10.3389/fimmu.2021.740632
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Intracerebral hemorrhage (ICH) has one of the worst prognoses among patients with stroke. Surgical measures have been adopted to relieve the mass effect of the hematoma, and developing targeted therapy against secondary brain injury (SBI) after ICH is equally essential. Numerous preclinical and clinical studies have demonstrated that perihematomal edema (PHE) is a quantifiable marker of SBI after ICH and is associated with a poor prognosis. Thus, PHE has been considered a promising therapeutic target for ICH. However, the findings derived from existing studies on PHE are disparate and unclear. Therefore, it is necessary to classify, compare, and summarize the existing studies on PHE. In this review, we describe the growth characteristics and relevant underlying mechanism of PHE, analyze the contributions of different risk factors to PHE, present the potential impact of PHE on patient outcomes, and discuss the currently available therapeutic strategies.</p>
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页数：16
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