Personalized pediatric anesthesia and pain management: problem-based review

被引：5

作者：

Packiasabapathy, Senthil ^{[1
]}

Rangasamy, Valluvan ^{[1
]}

Horn, Nicole ^{[1
]}

Hendrickson, Michele ^{[1
]}

Renschler, Janelle ^{[1
]}

Sadhasivam, Senthilkumar ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Indiana Univ Hlth, Riley Hosp Children, Dept Anesthesia, Indianapolis, IN 46202 USA

来源：

PHARMACOGENOMICS | 2020年 / 21卷 / 01期

关键词：

anesthesia; opioids; pain medicine; pediatric anesthesia; personalized medicine; pharmacogenetics; INDUCED RESPIRATORY DEPRESSION; HUMAN SERUM-CHOLINESTERASE; CATECHOL-O-METHYLTRANSFERASE; HUMAN LIVER-MICROSOMES; MALIGNANT HYPERTHERMIA; CYTOCHROME-P450; 2D6; GENETIC POLYMORPHISMS; POSTOPERATIVE NAUSEA; HUMAN BUTYRYLCHOLINESTERASE; DEVELOPMENTAL EXPRESSION;

D O I：

10.2217/pgs-2019-0108

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmacogenetics, the genetic influence on the interpersonal variability in drug response, has enabled tailored pharmacotherapy and emerging 'personalized medicine.' Although oncology spearheaded the clinical implementation of personalized medicine, other specialties are rapidly catching up. In anesthesia, classical examples of genetically mediated idiosyncratic reactions have been long known (e.g., malignant hyperthermia and prolonged apnea after succinylcholine). The last two decades have witnessed an expanding body of pharmacogenetic evidence in anesthesia. This review highlights some of the prominent pharmacogenetic associations studied in anesthesia and pain management, with special focus on pediatric anesthesia.

引用

页码：55 / 73

页数：19

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