Transforming growth factor-β signalling pathway in tendon healing

被引：25

作者：

Li, Yujie ^{[1
]}

Liu, Xinyue ^{[1
]}

Liu, Xueli ^{[1
]}

Peng, Yuanqiu ^{[1
]}

Zhu, Bin ^{[1
]}

Guo, Sheng ^{[2
]}

Wang, Chenglong ^{[2
]}

Wang, Dingxuan ^{[1
]}

Li, Sen ^{[1
,2
]}

机构：

[1] Southwest Med Univ, Inst Phys Educ, Luzhou, Sichuan, Peoples R China

[2] Southwest Med Univ, Tradit Chinese Med Hosp, Spinal Surg Dept, Luzhou, Sichuan, Peoples R China

来源：

GROWTH FACTORS | 2022年 / 40卷 / 3-4期

关键词：

Transforming growth factor-beta signalling; Smad; tendon injury; fibrosis; NF-KAPPA-B; TGF-BETA; COLLAGEN-SYNTHESIS; GENE-EXPRESSION; REPAIR; ACTIVATION; TISSUE; CELLS; SMAD3; SCLERAXIS;

D O I：

10.1080/08977194.2022.2082294

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transforming growth factor-beta(TGF-beta) plays an important but diverse role in tendon injuries, such as collagen synthesis, cell proliferation, cell differentiation, and cell adhesion, leading to tendon healing and tendon fibrosis. In the well-known canonical TGF-beta signalling pathway, TGF-beta activates Smad signalling through its two cell surface receptors, which leads to Smad-mediated transcriptional regulation and is also regulated by inhibitory Smads, forming a negative feedback regulatory pathway. In the context of the canonical TGF-beta signalling mechanism mediated by Smad, the activated receptors also send signals through other signal transducers, which in the backdrop of TGF-beta signaling are collectively known as non-Smad signalling pathways. Activated TGF-beta binds to the receptor and acts through these signalling pathways. Understanding the mechanism of the TGF-beta signalling pathway and its role in tendon repair is of great significance for targeting the TGF-beta signalling pathway to accelerate tendon healing and reduce tendon fibrosis.

引用

页码：98 / 107

页数：10

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