Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses

被引:409
作者
Han, Xianlin [1 ]
Yang, Kui [2 ]
Gross, Richard W. [2 ,3 ]
机构
[1] Sanford Burnham Med Res Inst, Orlando, FL 32827 USA
[2] Washington Univ, Sch Med, Dept Internal Med, Div Bioorgan Chem & Mol Pharmacol, St Louis, MO 63110 USA
[3] Washington Univ, Dept Chem, St Louis, MO 63130 USA
基金
美国国家卫生研究院;
关键词
electrospray ionization; MALDI; lipidomics; mass spectrometry; shotgun lipidomics; DOUBLE-BOND POSITION; ASSISTED LASER-DESORPTION; UNSATURATED FATTY-ACIDS; COLLISIONALLY ACTIVATED DISSOCIATION; THIN-LAYER-CHROMATOGRAPHY; MALDI-TOF MS; ELECTROSPRAY-IONIZATION; LIQUID-CHROMATOGRAPHY; QUANTITATIVE-ANALYSIS; BIOLOGICAL SAMPLES;
D O I
10.1002/mas.20342
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
Since our last comprehensive review on multi-dimensional mass spectrometry-based shotgun lipidomics (Mass Spectrom. Rev. 24 (2005), 367), many new developments in the field of lipidomics have occurred. These developments include new strategies and refinements for shotgun lipidomic approaches that use direct infusion, including novel fragmentation strategies, identification of multiple new informative dimensions for mass spectrometric interrogation, and the development of new bioinformatic approaches for enhanced identification and quantitation of the individual molecular constituents that comprise each cell's lipidome. Concurrently, advances in liquid chromatography-based platforms and novel strategies for quantitative matrix-assisted laser desorption/ionization mass spectrometry for lipidomic analyses have been developed. Through the synergistic use of this repertoire of new mass spectrometric approaches, the power and scope of lipidomics has been greatly expanded to accelerate progress toward the comprehensive understanding of the pleiotropic roles of lipids in biological systems. (C) 2011 Wiley Periodicals, Inc., Mass Spec Rev 31:134178, 2012
引用
收藏
页码:134 / 178
页数:45
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