A Case of Mixed Medullary and Follicular Cell Carcinoma of the Thyroid

被引：5

作者：

Ueki, Ikuko ^{[1
]}

Ando, Takao ^{[1
]}

Haraguchi, Ai ^{[1
]}

Horie, Ichiro ^{[1
]}

Imaizumi, Misa ^{[1
]}

Hayashi, Tomayoshi ^{[2
]}

Uga, Tatsuya ^{[3
]}

Usa, Toshiro ^{[1
]}

Kawakami, Atsushi ^{[1
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Endocrinol & Metab, Nagasaki, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pathol, Nagasaki, Japan

[3] Nagasaki Univ, Grad Sch Biomed Sci, Dept Surg, Nagasaki, Japan

来源：

INTERNAL MEDICINE | 2011年 / 50卷 / 12期

关键词：

medullary thyroid carcinoma; follicular thyroid cell; papillary thyroid carcinoma; GLAND; TUMOR; COMPONENTS;

D O I：

10.2169/internalmedicine.50.4749

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A medullary thyroid carcinoma is a malignant tumor derived from the C-cells of the thyroid. Despite their distinct embryological origin, medullary thyroid carcinomas are exceptionally accompanied by a tumor derived from the follicular cells; this is defined as mixed medullary and follicular cell carcinoma. There have been controversies regarding the origin of this rare mixed thyroid carcinoma questioning whether or not a mixed carcinoma originates from a common cancer stem cell. We present a case of mixed medullary and follicular cell carcinoma in which two thyroid carcinomas were found intermingled in the thyroid as well as in the metastatic cervical lymph nodes. We examined the tumor by immunostaining with thyroglobulin, calcitonin, and thyroid transcription factor-1, and also reviewed the literature and discuss the origin of this rare mixed thyroid carcinoma.

引用

页码：1313 / 1316

页数：4

共 14 条

[1]

[Anonymous], 2004, WHO CLASSIFICATION T

[2]

APEL RL, 1994, ARCH PATHOL LAB MED, V118, P1143

[3] Medullary and papillary tumors are frequently associated in the same thyroid gland without evidence of reciprocal influence in their biologic behavior [J].

Biscolla, RP ;

Ugolini, C ;

Sculli, M ;

Bottici, V ;

Castagna, MG ;

Romei, C ;

Cosci, B ;

Molinaro, E ;

Faviana, P ;

Basolo, F ;

Miccoli, P ;

Pacini, F ;

Pinchera, A ;

Elisei, R .

THYROID, 2004, 14 (11) :946-952

[4]

HALES M, 1982, CANCER-AM CANCER SOC, V50, P1352, DOI 10.1002/1097-0142(19821001)50:7<1352::AID-CNCR2820500722>3.0.CO

[5]

2-Q

[6] Concurrent occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same thyroid should be considered as coincidental [J].

Kim, Won Gu ;

Gong, Gyungyub ;

Kim, Eui Young ;

Kim, Tae Yong ;

Hong, Suck Joon ;

Kim, Won Bae ;

Shong, Young Kee .

CLINICAL ENDOCRINOLOGY, 2010, 72 (02) :256-263

[7]

LJUNGBERG O, 1983, CANCER-AM CANCER SOC, V52, P1053, DOI 10.1002/1097-0142(19830915)52:6<1053::AID-CNCR2820520621>3.0.CO

[8]

2-Q

[9] Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms [J].

Nonaka, Daisuke ;

Tang, Yunjia ;

Chiriboga, Luis ;

Rivera, Michael ;

Ghossein, Ronald .

MODERN PATHOLOGY, 2008, 21 (02) :192-200

[10] Mixed medullary-follicular carcinoma of the thyroid - A morphological, immunohistochemical and in situ hybridization analysis of 11 cases [J].

Papotti, M ;

Negro, F ;

Carney, JA ;

Bussolati, G ;

Lloyd, RV .

VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, 1997, 430 (05) :397-405

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