Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses

被引：393

作者：

Miyata, Kanjiro ^{[1
]}

Nishiyama, Nobuhiro ^{[1
]}

Kataoka, Kazunori ^{[1
,2
,3
,4
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Grad Sch Engn, Dept Mat Engn, Bunkyo Ku, Tokyo 1138656, Japan

[3] Univ Tokyo, Grad Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, Japan

[4] Univ Tokyo, Ctr NanoBio Integrat, Bunkyo Ku, Tokyo 1138656, Japan

来源：

CHEMICAL SOCIETY REVIEWS | 2012年 / 41卷 / 07期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

POLYION COMPLEX MICELLES; TRIGGERED INTRACELLULAR ACTIVATION; BLOCK-COPOLYMER MICELLES; PLASMID DNA; POLYPLEX MICELLES; IN-VITRO; POLY(ETHYLENE IMINE); BUFFERING CAPACITY; CROSS-LINKING; SIDE-CHAINS;

D O I：

10.1039/c1cs15258k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polymeric materials have been extensively developed as a delivery vehicle for nucleic acids over the past two decades. Many previous studies have demonstrated that synthetic delivery vehicles can be highly functionalized by chemical approaches to overcome biological barriers in nucleic acid delivery, similar to viruses. Based on our current knowledge, this tutorial review describes rational strategies in the design of polymeric materials to achieve construction of the versatile vehicles, that is "artificial viruses", for successful gene therapy, especially focusing on the chemical structures with the minimal adverse effects.

引用

页码：2562 / 2574

页数：13

共 84 条

[1] Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation [J].

Akagi, D. ;

Oba, M. ;

Koyama, H. ;

Nishiyama, N. ;

Fukushima, S. ;

Miyata, T. ;

Nagawa, H. ;

Kataoka, K. .

GENE THERAPY, 2007, 14 (13) :1029-1038

[2] The transport of nanosized gene carriers unraveled by live-cell imaging [J].

Bausinger, R ;

von Gersdorff, K ;

Braeckmans, K ;

Ogris, M ;

Wagner, E ;

Bräuchle, C ;

Zumbusch, A .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (10) :1568-1572

[3] Proton coordination by polyamine compounds in aqueous solution [J].

Bencini, A ;

Bianchi, A ;

Garcia-España, E ;

Micheloni, M ;

Ramirez, JA .

COORDINATION CHEMISTRY REVIEWS, 1999, 188 :97-156

[4] Intracellular route and transcriptional competence of polyethylenimine-DNA complexes [J].

Bieber, T ;

Meissner, W ;

Kostin, S ;

Niemann, A ;

Elsasser, HP .

JOURNAL OF CONTROLLED RELEASE, 2002, 82 (2-3) :441-454

[5] A VERSATILE VECTOR FOR GENE AND OLIGONUCLEOTIDE TRANSFER INTO CELLS IN CULTURE AND IN-VIVO - POLYETHYLENIMINE [J].

BOUSSIF, O ;

LEZOUALCH, F ;

ZANTA, MA ;

MERGNY, MD ;

SCHERMAN, D ;

DEMENEIX, B ;

BEHR, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7297-7301

[6] Intracellular Trafficking and Subcellular Distribution of a Large Array of HPMA Copolymers [J].

Callahan, Jon ;

Kopeckova, Pavla ;

Kopecek, Jindrich .

BIOMACROMOLECULES, 2009, 10 (07) :1704-1714

[7] Angiogenesis in cancer and other diseases [J].

Carmeliet, P ;

Jain, RK .

NATURE, 2000, 407 (6801) :249-257

[8] Polyethylene glycol-grafted poly-L-lysine as polymeric gene carrier [J].

Choi, YH ;

Liu, F ;

Kim, JS ;

Choi, YK ;

Park, JS ;

Kim, SW .

JOURNAL OF CONTROLLED RELEASE, 1998, 54 (01) :39-48

[9]

Fedorova E., 2006, J GENE MED, V8, P414

[10] In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. [J].

Fischer, D ;

Li, YX ;

Ahlemeyer, B ;

Krieglstein, J ;

Kissel, T .

BIOMATERIALS, 2003, 24 (07) :1121-1131

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