Efficacy of Preerythrocytic and Blood-Stage Malaria Vaccines Can Be Assessed in Small Sporozoite Challenge Trials in Human Volunteers

被引：37

作者：

Roestenberg, Meta ^{[1
]}

de Vlas, Sake J. ^{[2
]}

Nieman, An-Emmie ^{[3
]}

Sauerwein, Robert W. ^{[1
]}

Hermsen, Cornelus C. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands

[2] Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands

[3] Vrije Univ Amsterdam Med Ctr, Dept Med Microbiol, Amsterdam, Netherlands

来源：

JOURNAL OF INFECTIOUS DISEASES | 2012年 / 206卷 / 03期

关键词：

POLYMERASE-CHAIN-REACTION; PLASMODIUM-FALCIPARUM;

D O I：

10.1093/infdis/jis355

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of a vaccine against malaria has public health priority. In a controlled setting, preliminary data on the efficacy of Plasmodium falciparum vaccine candidates can be obtained by exposing immunized human volunteers to the bites of laboratory-reared P. falciparum-infected mosquitoes. Using empirical data, we show that these trials, with small numbers of volunteers, are sufficiently powered to detect protective biological effects induced by preerythrocytic and/or blood-stage candidate vaccines if parasitemia is measured daily by quantitative polymerase chain reaction. Sporozoite challenge trials are thus a powerful tool for early selection of candidates that warrant efficacy of trials in the field.

引用

页码：319 / 323

页数：5

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