Flexible Drift Tube for High Resolution Ion Mobility Spectrometry (Flex-DT-IMS)

被引:30
|
作者
Smith, Barry L. [1 ]
Boisdon, Cedric [1 ]
Young, Iain S. [2 ]
Praneenararat, Thanit [3 ]
Vilaivan, Tirayut [3 ]
Maher, Simon [1 ]
机构
[1] Univ Liverpool, Dept Elect Engn & Elect, Liverpool L69 3GJ, Merseyside, England
[2] Univ Liverpool, Inst Integrat Biol, Liverpool L69 3BX, Merseyside, England
[3] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok 10330, Thailand
基金
英国工程与自然科学研究理事会;
关键词
PRESSURE CHEMICAL-IONIZATION; ELECTROSPRAY-IONIZATION; RESOLVING POWER; MASS-SPECTROMETRY; EXPLOSIVES; FIELD; GATE; DISTRIBUTIONS; SEPARATION;
D O I
10.1021/acs.analchem.0c01357
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
This paper describes, in detail, the development of a novel, low-cost, and flexible drift tube (DT) along with an associated ion mobility spectrometer system. The DT is constructed from a flexible printed circuit board (PCB), with a bespoke "dog-leg" track design, that can be rolled up for ease of assembly. This approach incorporates a shielding layer, as part of the flexible PCB design, and represents the minimum dimensional footprint conceivable for a DT. The low thermal mass of the polyimide substrate and overlapping electrodes, as afforded by the dog-leg design, allow for efficient heat management and high field linearity within the tube-achieved from a single PCB. This is further enhanced by a novel double-glazing configuration which provides a simple and effective means for gas management, minimizing thermal variation within the assembly. Herein, we provide a full experimental characterization of the flexible DT ion mobility spectrometer (Flex-DT-IMS) with corresponding electrodynamic (Simion 8.1) and fluid dynamic (SolidWorks) simulations. The Flex-DT-IMS is shown to have a resolution >80 and a detection limit of low nanograms for the analysis of common explosives (RDX, PETN, HMX, and TNT).
引用
收藏
页码:9104 / 9112
页数:9
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