Molecular characterization of Escherichia coli FtsE and FtsX

被引：82
作者：
de Leeuw, E
Graham, B
Phillips, GJ
ten Hagen-Jongman, CM
Oudega, B
Luirink, J
机构：
[1] Biocentrum Amsterdam, Inst Mol Biol Sci, Dept Microbiol, NL-1081 HV Amsterdam, Netherlands
[2] Iowa State Univ, Dept Microbiol, Ames, IA 50011 USA
来源：
MOLECULAR MICROBIOLOGY | 1999年 / 31卷 / 03期
关键词：
D O I：
10.1046/j.1365-2958.1999.01245.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The genes ftsE and ftsX are organized in one operon together with ftsY. FtsY codes for the receptor of the signal recognition particle (SRP) that functions in targeting a subset of inner membrane proteins. We have found no indications for a structural relationship between FtsE/X and FtsY. Evidence is presented that FtsE and FtsX form a complex in the inner membrane that bears the characteristics of an ATP-binding cassette (ABC)-type transporter. FtsE is a hydrophilic nucleotide-binding protein that has a tendency to dimerize and associates with the inner membrane through an interaction with the integral membrane protein FtsX. An FtsE null mutant showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport.
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收藏
页码：983 / 993
页数：11
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