Chronic bilateral electrical stimulation of the subthalamic nucleus for the treatment of advanced Parkinson's disease

被引：21

作者：

Capus, L ^{[1
]}

Melatini, A

Zorzon, M

Torre, P

Carraro, N

Moretti, D

Gioulis, M

Moretti, R

Sarra, MV

Marsala, SZ

机构：

[1] Univ Trieste, Cattinara Hosp, Dept Neurol, Trieste, Italy

[2] Cattinara Hosp, Div Neurosurg, Trieste, Italy

来源：

NEUROLOGICAL SCIENCES | 2001年 / 22卷 / 01期

关键词：

Electrical Stimulation; Motor Function; Preliminary Report; Perioperatory Complication; Subthalamic Nucleus;

D O I：

10.1007/s100720170045

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Preliminary reports in patients with Parkinson's disease (PD) showed that subthalamic nucleus (STN) stimulation was able to reverse parkinsonian state. Since 1998 we evaluated the safety and the efficacy of STN stimulation in 7 patients affected by advanced PD. All patients were included using CAPIT protocol. Motor functions and quality of life were evaluated, before and after surgery, with UPDRS and PDQ38, respectively. At the g-month follow-up, the off medication/on stimulation UPDRS motor score improved by 50.6% and the on medication/on stimulation by 20.3%. Motor fluctuations were reduced by 57.2% and dyskinesias by 73.5%. The total L-dopa equivalent daily dose was reduced by 40.7%. PDQ38 ameliorated by 49.9%. We did not observe any perioperatory complication and only mild and tolerable side effects after stimulation.

引用

页码：57 / 58

页数：2

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