Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana

被引：65

作者：

Pan, Li-Li ^{[1
,4
]}

Fang, Ping-Lei ^{[1
]}

Zhang, Xing-Jie ^{[2
,3
]}

Ni, Wei ^{[1
]}

Li, Lei ^{[1
]}

Yang, Liu-Meng ^{[2
,3
]}

Chen, Chang-Xiang ^{[1
]}

Zheng, Yong-Tang ^{[2
,3
]}

Li, Chang-Tian ^{[4
]}

Hao, Xiao-Jiang ^{[1
]}

Liu, Hai-Yang ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China

[4] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 06期

关键词：

PROSTRATIN; ACTIVATION; ROOTS; HIV-1;

D O I：

10.1021/np200058c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Investigation of whole plants of Euphorbia fischeriana afforded three new tigliane-diterpenoid glycosides, fischerosides A-C (1-3), together with 11 known diterpenoids. Fischerosides A-C (1-3) are the first tigliane-type diterpenoid glucosides. Their structures were determined by a combination of 1D and 2D NMR, MS, and acid hydrolysis. Inhibitory activity against HIV-1 was assessed for compounds 1-5. The new compound 3 showed an EC(50) value of 0.02 mu M and a therapeutic index (TI) of 17.50, while prostratin (4) and 12-deoxyphorbol-13,20-diacetate (5) showed significantly greater anti-HIV-1 activity.

引用

页码：1508 / 1512

页数：5

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