Cyclopentyl Methyl Ether: An Alternative Solvent for Palladium-Catalyzed Direct Arylation of Heteroaromatics

被引：58
作者：
Beydoun, Kassem [1 ]
Doucet, Henri [1 ]
机构：
[1] Univ Rennes 1, CNRS, Inst Sci Chim Rennes, UMR 6226, F-35042 Rennes, France
来源：
CHEMSUSCHEM | 2011年 / 4卷 / 04期
关键词：
aryl bromides; homogeneous catalysis; cyclopentyl methyl ether; heteroaromatics; palladium; DIRECT C-2 ARYLATION; INCLUDING FREE (NH)-IMIDAZOLE; C-H ARYLATION; ROOM-TEMPERATURE; ARYL HALIDES; REGIOSELECTIVE SYNTHESIS; COUPLING REACTIONS; DERIVATIVES; EFFICIENT; THIAZOLES;
D O I：
10.1002/cssc.201000405
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Some ethers, such as cyclopentyl methyl ether and di-n-butyl ether, which can be considered as "greener" solvents than N,N-dimethylacetamide (DMAc) or DMF, can be advantageously employed for the palladium-catalyzed direct arylation of heter-oaromatics. In the presence of such ethers and only 0.5-1 mol% of palladium catalysts at 125-150 degrees C, the direct 5-arylation of thiazoles, thiophenes, or furans by using aryl bromides as coupling partners proceeds in moderate to high yields.
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收藏
页码：526 / 534
页数：9
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