Investigating the Dialysis Treatment Using Hollow Fiber Membrane: A New Approach by CFD

被引:5
作者
Magalhaes, Hortencia L. F. [1 ]
Gomez, Ricardo S. [2 ]
Leite, Boniek E. [3 ]
Nascimento, Jessica B. S. [3 ,4 ]
Brito, Mirenia K. T. [3 ]
Araujo, Morgana, V [3 ]
Cavalcante, Daniel C. M. [5 ]
Lima, Elisiane S. [3 ]
Lima, Antonio G. B. [2 ,3 ]
Neto, Severino R. Farias [1 ,3 ]
机构
[1] Univ Fed Campina Grande, Dept Chem Engn, BR-58429900 Campina Grande, Paraiba, Brazil
[2] Univ Fed Campina Grande, Dept Mech Engn, BR-58429900 Campina Grande, Paraiba, Brazil
[3] Univ Fed Campina Grande, Dept Proc Engn, BR-58429900 Campina Grande, Paraiba, Brazil
[4] Univ Estadual Santa Cruz, Dept Exact Sci & Technol, BR-46662900 Ilheus, BA, Brazil
[5] Fed Inst Educ Sci & Technol Sertao Pernambucano, BR-56915899 Serra Talhada, Brazil
关键词
computational fluid dynamics; hemodialysis; membrane; MASS-TRANSFER; SOLUTE REMOVAL; TRANSPORT; SIMULATION;
D O I
10.3390/membranes12070710
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Due to the increase in the number of people affected by chronic renal failure, the demand for hemodialysis treatment has increased considerably over the years. In this sense, theoretical and experimental studies to improve the equipment (hemodialyzer) are extremely important, due to their potential impact on the patient's life quality undergoing treatment. To contribute to this research line, this work aims to study the fluid behavior inside a hollow fiber dialyzer using computational fluid dynamics. In that new approach, the blood is considered as multiphase fluid and the membrane as an extra flow resistance in the porous region (momentum sink). The numerical study of the hemodialysis process was based on the development of a mathematical model that allowed analyzing the performance of the system using Ansys (R) Fluent software. The predicted results were compared with results reported in the literature and a good concordance was obtained. The simulation results showed that the proposed model can predict the fluid behavior inside the hollow fiber membrane adequately. In addition, it was found that the clearance decreases with increasing radial viscous resistance, with greater permeations in the vicinity of the lumen inlet region, as well as the emergence of the retrofiltration phenomenon, characteristic of this type of process. Herein, velocity, pressure, and volumetric fraction fields are presented and analyzed.
引用
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页数:23
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