Polymorph selection: Challenges for the future?

被引：193

作者：

Blagden, N ^{[1
]}

Davey, RJ

机构：

[1] Univ Bradford, Sch Pharm, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England

[2] Univ Manchester, Dept Chem Engn, Mol Mat Ctr, Manchester M60 1QD, Lancs, England

来源：

CRYSTAL GROWTH & DESIGN | 2003年 / 3卷 / 06期

关键词：

D O I：

10.1021/cg030025k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This contribution reviews the area of polymorph selection during solution crystallization using known and predicted structures. In particular, an overview of what has been learned about the relationship between structure and kinetics and of the interplay between thermodynamics and kinetics is presented. This review adds to the debate by discussing the future challenges that we envisage in realizing polymorph selection as a crystal engineering exercise by highlighting the role that a packing landscape approach may contribute in manipulating the selection of a polymorph.

引用

页码：873 / 885

页数：13