Biochemical and Hematological Relationship with the Evaluation of Autonomic Dysfunction by Heart Rate Recovery in Patients with Asthma and Type 2 Diabetes

被引：1

作者：

Aztatzi-Aguilar, O. Gamaliel ^{[1
]}

Vargas-Dominguez, Claudia ^{[1
]}

Debray-Garcia, Yazmin ^{[1
]}

Ortega-Romero, Manolo S. ^{[1
,2
]}

Almeda-Valdes, Paloma ^{[3
]}

Aguilar-Salinas, Carlos A. ^{[3
]}

Naranjo-Meneses, M. Augusta ^{[3
]}

Mena-Orozco, D. Abril ^{[3
]}

Lam-Chung, Cesar E. ^{[3
]}

Cruz-Bautista, Ivette ^{[3
]}

Sierra-Vargas, M. Patricia ^{[4
,5
]}

机构：

[1] Inst Enfermedades Resp Ismael Cosio Villegas, Dept Invest Toxicol & Med Ambiental, Mexico City 14080, DF, Mexico

[2] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Mexico City 07360, DF, Mexico

[3] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Invest Enfermedades Metab, Mexico City 14080, DF, Mexico

[4] Inst Enfermedades Resp Ismael Cosio Villegas, Subdirecc Invest Clin, Mexico City 14080, DF, Mexico

[5] Univ La Salle, Fac Mexicana Med, Mexico City 14000, DF, Mexico

来源：

DIAGNOSTICS | 2021年 / 11卷 / 12期

关键词：

biochemical evaluation; hematological evaluation; autonomic dysfunction; heart rate recovery; 6-min walking test; INSULIN-RESISTANCE; RATE-VARIABILITY; EXERCISE; INFLAMMATION;

D O I：

10.3390/diagnostics11122187

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There are several methods to assess the function of the autonomic nervous system. Among them, heart rate recovery (HRR) is an accepted, easy, low-cost technique. Different pathological conditions have been related to the development of autonomic dysfunction. Our study aimed to evaluate the relationship between HRR and HRR-derived parameters in ambulatory patients with asthma or type 2 diabetes followed at the National Institutes of Health in Mexico City. A total of 78 participants, 50 women and, 28 men were enrolled; anthropometric, respiratory evaluations, and fasting blood samples were taken before participants performed a 6-min walking test (6MWT). Abnormal HRR was defined as a drop of <= 8 and <= 11 beats/min at 1 or 2 min and correlated negatively with basal oxygen saturation at 1 min. Heart rate at 1 min, correlated negatively with final oxygen saturation (p < 0.01). Statistically significant negative correlations were also observed between red cell count and white blood cell count and HOMA-IR with a p < 0.01. Since discrete hematological but significant changes correlated with HRR and HRR-derived parameters, we consider that these measures are helpful in clinical settings to identify subclinical autonomic dysfunction that permits us to prevent or anticipate chronic and fatal clinical outcomes.

引用

页数：15