Green synthesis of 2-pyrazinones in deep eutectic solvents: From α-chloro oximes to peptidomimetic scaffolds

被引：24

作者：

Perrone, Serena ^{[1
]}

Capua, Martina ^{[1
]}

Messa, Francesco ^{[1
,2
]}

Salomone, Antonio ^{[1
]}

Troisi, Luigino ^{[1
]}

机构：

[1] Univ Salento, Dipartimento Sci & Tecnol Biol & Ambientali, I-73100 Lecce, Italy

[2] Univ Bari Aldo Moro, Dipartimento Farm Sci Farmaco, Consorzio CINMPIS, Via E Orabona 4, I-70125 Bari, Italy

来源：

TETRAHEDRON | 2017年 / 73卷 / 43期

关键词：

alpha-Chloro oxime; 2-Pyrazinone; Deep eutectic solvents; Green chemistry; Peptidomimetics; PALLADIUM-CATALYZED CARBONYLATION; BASE-INDUCED CONDENSATION; FACTOR VIIA COMPLEX; BETA-LACTAMS; PYRAZINONE ANTITHROMBOTICS; STEREOSELECTIVE-SYNTHESIS; SELECTIVE INHIBITORS; THROMBIN INHIBITORS; DERIVATIVES; 2(1H)-PYRAZINONES;

D O I：

10.1016/j.tet.2017.09.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and green synthesis of 2-pyrazinones in deep eutectic solvents (DESs) is described. Treatment of aromatic alpha-chloro oximes with aliphatic amines at 110 degrees C in choline chloride based DESs resulted in a straightforward and efficient assembly of 1,3,5-trisubstituted-2(1H)-pyrazinones. The protocol, featuring mild reaction conditions and avoiding common volatile organic solvents, affords a safe and sustainable approach to original peptidomimetic scaffolds. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：6193 / 6198

页数：6

共 38 条

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