The Exposome: Making Chemical Exposures Relevant to Biology Instruction

被引:0
作者
Haine, Dana Brown [1 ]
机构
[1] Univ North Carolina Chapel Hill, Inst Environm, CB 1105, Chapel Hill, NC 27599 USA
关键词
biomarker; cancer; carcinogen; DNA; DNA adduct; exposome; mutation; Superfund; vinyl chloride;
D O I
10.1525/abt.2018.80.8.600
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
"Investigating the Exposome: Vinyl Chloride Exposure, DNA Damage & Repair" is a data interpretation and graphing activity that provides students a relevant context in which to explore and refine what they know about DNA structure and function, mutation, DNA repair, and cancer formation. The activity utilizes published scientific data and invites students to assess the impact of exposure to vinyl chloride on DNA in an effort to introduce them to the concept of the exposome and engage them in this exciting field of scientific research.
引用
收藏
页码:600 / 607
页数:8
相关论文
共 6 条
  • [1] [Anonymous], 2006, Toxicological Profile for Hydrogen Sulfide
  • [2] The endogenous exposome
    Nakamura, Jun
    Mutlu, Esra
    Sharma, Vyom
    Collins, Leonard
    Bodnar, Wanda
    Yu, Rui
    Lai, Yongquan
    Moeller, Benjamin
    Lu, Kun
    Swenberg, James
    [J]. DNA REPAIR, 2014, 19 : 3 - 13
  • [3] An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride
    Pottenger, Lynn H.
    Andrews, Larry S.
    Bachman, Ammie N.
    Boogaard, Peter J.
    Cadet, Jean
    Embry, Michelle R.
    Farmer, Peter B.
    Himmelstein, Matthew W.
    Jarabek, Annie M.
    Martin, Elizabeth A.
    Mauthe, Robert J.
    Persaud, Rudranath
    Preston, R. Julian
    Schoeny, Rita
    Skare, Julie
    Swenberg, James A.
    Williams, Gary M.
    Zeiger, Errol
    Zhang, Fagen
    Kim, James H.
    [J]. CRITICAL REVIEWS IN TOXICOLOGY, 2014, 44 (04) : 348 - 391
  • [4] Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Epidemiology, and Risk Assessment
    Swenberg, James A.
    Lu, Kun
    Moeller, Benjamin C.
    Gao, Lina
    Upton, Patricia B.
    Nakamura, Jun
    Starr, Thomas B.
    [J]. TOXICOLOGICAL SCIENCES, 2011, 120 : S130 - S145
  • [5] U. S. Environmental Protection Agency, 2017, TSCA TOX SUBST CONTR
  • [6] Complementing the genome with an "exposome": The outstanding challenge of environmental exposure measurement in molecular epidemiology
    Wild, CP
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (08) : 1847 - 1850