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Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Epidemiol & Biostat,Mol Epidemiol Unit, Leeds LS2 9JT, W Yorkshire, England Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Epidemiol & Biostat,Mol Epidemiol Unit, Leeds LS2 9JT, W Yorkshire, England