Therapeutic effects of curcumin on experimental autoimmune myasthenia gravis

被引：0

作者：

Su, Zhongqian ^{[1
]}

Huang, Yuanyuan ^{[2
]}

Huang, Shihao ^{[3
]}

Yang, Dehao ^{[2
]}

Wang, Qingqing ^{[4
]}

Chen, Ying ^{[2
]}

Chen, Zhibo ^{[2
]}

Jiang, Yanyan ^{[1
]}

Xiang, Weiwei ^{[2
]}

Li, Xiang ^{[2
]}

Weng, Yiyun ^{[2
]}

Huang, Xiangdong ^{[1
]}

Liu, Fang ^{[5
]}

Han, Liya ^{[1
]}

Zhang, Xu ^{[2
]}

Li, Jia ^{[2
]}

机构：

[1] Wenzhou Cent Hosp, Dept Neurol, Wenzhou 325000, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, 2 Fuxue Lane, Wenzhou 325000, Zhejiang, Peoples R China

[3] Wenzhou Med Univ, Affiliated Hosp 1, Dept Surg, Wenzhou 325000, Zhejiang, Peoples R China

[4] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthoped Surg, Wenzhou 325000, Zhejiang, Peoples R China

[5] Zhejiang Prov Peoples Hosp, Dept Neurol, 158 Shangtang Rd, Hangzhou 310000, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2018年 / 11卷 / 10期

关键词：

Experimental autoimmune myasthenia gravis; curcumin; Th1/Th2/Th17/Treg; REGULATORY T-CELLS; RECEPTOR; BETA; T(H)17;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Experimental autoimmune myasthenia gravis (EAMG) is a B-cell-mediated and T-cell-dependent autoimmune disease of the neuromuscular junction in which the nicotinic acetylcholine receptor (AchR) acts as an autoantigen. Curcumin is a yellow acidic phenolic substance extracted from the rhizome of the plant turmeric. It has various pharmacological properties, including anti-oxidant, anti-cancer, and anti-inflammatory effects. However, the immunoregulatory effects of curcumin on MG and EAMG are still unclear. Hence, this study aimed to investigate the effects and potential mechanisms of curcumin on EAMG. Female Lewis rats were randomly divided into three groups: CFA group (n = 9), EAMG group (n = 8), and curcumin group (n = 7). It was found that curcumin can ameliorate clinical symptoms of EAMG rats and protect AchR from being destroyed in the neuromuscular junction (NMJ) of EAMG rats. Moreover, it was confirmed that curcumin can regulate the balance of Th1/Th2/Th17/Treg in spleens of EAMG rats. In conclusion, this study shows that curcumin can ameliorate EAMG by regulating the balance of Th1, Th2, Th17, and Treg.

引用

页码：10646 / 10652

页数：7

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