Estrogen and Autoimmune Disease

被引：43

作者：

Walker, Sara E. ^{[1
,2
]}

机构：

[1] Univ Missouri, Dept Internal Med, Las Cruces, NM 88011 USA

[2] Univ Missouri, Dept Pathol & Anat Sci, Las Cruces, NM 88011 USA

来源：

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY | 2011年 / 40卷 / 01期

关键词：

Autoimmunity; Estrogen; Systemic lupus erythematosus; Rheumatoid arthritis; Sjogren's syndrome; Multiple sclerosis; SYSTEMIC-LUPUS-ERYTHEMATOSUS; HORMONE REPLACEMENT THERAPY; OVULATION-INDUCTION THERAPY; RHEUMATOID-ARTHRITIS; DOUBLE-BLIND; ORAL-CONTRACEPTIVES; GENE POLYMORPHISMS; OVARIAN-FUNCTION; SEX-HORMONES; WOMEN;

D O I：

10.1007/s12016-010-8199-x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Estrogenic hormones possess both immunostimulating and immunosuppressive properties. In systemic lupus erythematosus (SLE), pregnancy is associated with disease flares. In some situations, exogenous estrogen predisposes to development of new SLE, flares of preexisting SLE, and thromboses in susceptible individuals. In contrast, treatment with exogenous estrogen protects postmenopausal rheumatoid arthritis (RA) patients from active RA and osteoporosis. The search for estrogen-like compounds with anti-inflammatory properties may expand treatment options in RA.

引用

页码：60 / 65

页数：6

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