THE PHENYLALANYL-TRNA SYNTHETASE IS A DRUGGABLE TARGET IN PLASMODIUM FALCIPARUM

被引:0
作者
Sakata-Kato, Tomoyo [1 ]
Kato, Nobutaka [2 ]
Comer, Eamon [2 ]
Lukens, Amanda K. [2 ]
Corey, Victoria C. [3 ]
Winzeler, Elizabeth A. [3 ]
Scherer, Christina A. [2 ]
Schreiber, Stuart L. [2 ]
Wirth, Dyann F. [1 ]
机构
[1] Harvard TH Chan Sch Publ Hlth, Boston, MA USA
[2] Broad Inst, Cambridge, MA USA
[3] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA
关键词
D O I
暂无
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
1206
引用
收藏
页码:367 / 367
页数:1
相关论文
共 50 条
[21]   Oxidation of phenylalanyl-tRNA synthetase positively regulates translational quality control [J].
Steiner, Rebecca E. ;
Kyle, Amanda M. ;
Ibba, Michael .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (20) :10058-10063
[22]   Computational strategy for binding of phenylalanine analogs in phenylalanyl-tRNA synthetase. [J].
Kekenes-Huskey, PM ;
Tanrikulu, IC ;
Kam, VWT ;
Vaidehi, N ;
Goddard, WA .
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 :U757-U757
[23]   Phenylalanyl-tRNA synthetase gene, pheT, from Synechococcus PCC 7942 [J].
Cranenburgh, RM ;
Robinson, NJ .
JOURNAL OF APPLIED PHYCOLOGY, 1996, 8 (01) :81-82
[24]   PURIFICATION AND SOME PROPERTIES OF PHENYLALANYL-TRNA SYNTHETASE FROM BAKERS YEAST [J].
FASIOLO, F ;
BEFORT, N ;
BOULANGER, Y ;
EBEL, JP .
BIOCHIMICA ET BIOPHYSICA ACTA, 1970, 217 (02) :305-+
[25]   The Role of a Novel Auxiliary Pocket in Bacterial Phenylalanyl-tRNA Synthetase Druggability [J].
Abibi, Ayome ;
Ferguson, Andrew D. ;
Fleming, Paul R. ;
Gao, Ning ;
Hajec, Laurel I. ;
Hu, Jun ;
Laganas, Valerie A. ;
McKinney, David C. ;
McLeod, Sarah M. ;
Prince, D. Bryan ;
Shapiro, Adam B. ;
Buurman, Ed T. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (31) :21651-21662
[26]   Iron-regulated phenylalanyl-tRNA synthetase activity in Azotobacter vinelandii [J].
Page, WJ ;
Mehrotra, M ;
Vande Woestyne, M ;
Tindale, AE ;
Choy, SLK ;
Macyk, AS ;
Leskiw, BK .
FEMS MICROBIOLOGY LETTERS, 2003, 218 (01) :15-21
[27]   Target safety assessments: evaluation of the toxicological risk of targeting FRS (Phenylalanyl-tRNA Synthetase) in the treatment of Malaria [J].
Barber, J. ;
Baud, D. ;
Willis, P. ;
Sadler, C. ;
Roberts, R. .
TOXICOLOGY LETTERS, 2019, 314 :S85-S86
[28]   Structure at 2.6 Å resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese [J].
Fishman, R ;
Ankilova, V ;
Moor, N ;
Safro, M .
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2001, 57 :1534-1544
[29]   Loss of editing activity during the evolution of mitochondrial phenylalanyl-tRNA synthetase [J].
Roy, H ;
Ling, JQ ;
Alfonzo, J ;
Ibba, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (46) :38186-38192
[30]   Domains of phenylalanyl-tRNA synthetase from Thermus thermophilus required for aminoacylation [J].
Lechler, A ;
Kreutzer, R .
FEBS LETTERS, 1997, 420 (2-3) :139-142