Fabrication of fillable microparticles and other complex 3D microstructures

被引：179

作者：

McHugh, Kevin J. ^{[1
]}

Nguyen, Thanh D. ^{[1
,2
]}

Linehan, Allison R. ^{[1
]}

Yang, David ^{[1
]}

Behrens, Adam M. ^{[1
]}

Rose, Sviatlana ^{[1
]}

Tochka, Zachary L. ^{[1
]}

Tzeng, Stephany Y. ^{[1
]}

Norman, James J. ^{[1
,3
]}

Anselmo, Aaron C. ^{[1
,4
]}

Xu, Xian ^{[1
]}

Tomasic, Stephanie ^{[1
]}

Taylor, Matthew A. ^{[1
]}

Lu, Jennifer ^{[1
]}

Guarecuco, Rohiverth ^{[1
]}

Langer, Robert ^{[1
]}

Jaklenec, Ana ^{[1
]}

机构：

[1] MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA

[3] US FDA, Silver Spring, MD 20993 USA

[4] Univ North Carolina Chapel Hill, Div Pharmacoengn & Mol Pharmaceut, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

来源：

SCIENCE | 2017年 / 357卷 / 6356期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

MICROENCAPSULATION; MONODISPERSE; CHALLENGES; SCAFFOLDS; RELEASE; SHAPE;

D O I：

10.1126/science.aaf7447

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Three-dimensional (3D) microstructures created by microfabrication and additive manufacturing have demonstrated value across a number of fields, ranging from biomedicine to microelectronics. However, the techniques used to create these devices each have their own characteristic set of advantages and limitations with regards to resolution, material compatibility, and geometrical constraints that determine the types of microstructures that can be formed. We describe a microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), and create injectable pulsatile drug-delivery microparticles, pH sensors, and 3D microfluidic devices that we could not produce using traditional 3D printing. SEAL allows us to generate microstructures with complex geometry at high resolution, produce fully enclosed internal cavities containing a solid or liquid, and use potentially any thermoplastic material without processing additives.

引用

页码：1138 / +

页数：5

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