Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARSC-oV-2) Infection in Children of Healthcare Workers With Confirmed Coronavirus Disease 2019 (COVID-19)

被引:2
作者
Ladhani, Shamez N. [1 ]
Andrews, Nick [1 ]
Aiano, Felicity [1 ]
Baawuah, Frances [1 ]
Amin-Chowdhury, Zahin [1 ]
Brown, Kevin E. [1 ]
Amirthalingam, Gayatri [1 ]
Ramsay, Mary E. [1 ]
Waterfield, Thomas [2 ]
机构
[1] Immunisat & Countermeasures Div, 61 Colindale Ave, London NW9 5EQ, England
[2] Queens Univ Belfast, Ctr Expt Med, Wellcome Wolfson Inst Expt Med, Belfast, Antrim, North Ireland
关键词
COVID-19; children; secondary attack rates; healthcare workers;
D O I
10.1093/cid/ciaa1737
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates. Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P < .001): 20/21 (95.2%) children were seropositive in 9 families and none of 23 children in 12 other families.
引用
收藏
页码:E260 / E263
页数:4
相关论文
共 18 条
[1]   Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong [J].
Adam, Dillon C. ;
Wu, Peng ;
Wong, Jessica Y. ;
Lau, Eric H. Y. ;
Tsang, Tim K. ;
Cauchemez, Simon ;
Leung, Gabriel M. ;
Cowling, Benjamin J. .
NATURE MEDICINE, 2020, 26 (11) :1714-+
[2]   The Power of Antibody-Based Surveillance [J].
Alter, Galit ;
Seder, Robert .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (18) :1782-1784
[3]   Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (Publication with Expression of Concern) [J].
Corman, Victor M. ;
Landt, Olfert ;
Kaiser, Marco ;
Molenkamp, Richard ;
Meijer, Adam ;
Chu, Daniel K. W. ;
Bleicker, Tobias ;
Bruenink, Sebastian ;
Schneider, Julia ;
Schmidt, Marie Luisa ;
Mulders, Daphne G. J. C. ;
Haagmans, Bart L. ;
van der Veer, Bas ;
van den Brink, Sharon ;
Wijsman, Lisa ;
Goderski, Gabriel ;
Romette, Jean-Louis ;
Ellis, Joanna ;
Zambon, Maria ;
Peiris, Malik ;
Goossens, Herman ;
Reusken, Chantal ;
Koopmans, Marion P. G. ;
Drosten, Christian .
EUROSURVEILLANCE, 2020, 25 (03) :23-30
[4]   Epidemiology of COVID-19 Among Children in China [J].
Dong, Yuanyuan ;
Mo, Xi ;
Hu, Yabin ;
Qi, Xin ;
Jiang, Fan ;
Jiang, Zhongyi ;
Tong, Shilu .
PEDIATRICS, 2020, 145 (06)
[5]  
ECDC, 2020, COVID 19 CHILDR ROL
[6]   First experience of COVID-19 screening of health-care workers in England [J].
Hunter, Ewan ;
Price, David A. ;
Murphy, Elizabeth ;
van der Loeff, Ina Schim ;
Baker, Kenneth F. ;
Lendrem, Dennis ;
Lendrem, Clare ;
Schmid, Matthias L. ;
Pareja-Cebrian, Lucia ;
Welch, Andrew ;
Payne, Brendan A. I. ;
Duncan, Christopher J. A. .
LANCET, 2020, 395 (10234) :E77-E78
[7]   COVID-19 in children: analysis of the first pandemic peak in England [J].
Ladhani, Shamez N. ;
Amin-Chowdhury, Zahin ;
Davies, Hannah G. ;
Aiano, Felicity ;
Hayden, Iain ;
Lacy, Joanne ;
Sinnathamby, Mary ;
de Lusignan, Simon ;
Demirjian, Alicia ;
Whittaker, Heather ;
Andrews, Nick ;
Zambon, Maria ;
Hopkins, Susan ;
Ramsay, Mary Elizabeth .
ARCHIVES OF DISEASE IN CHILDHOOD, 2020, 105 (12) :1180-1185
[8]  
Lei H, J INFECT
[9]  
Li W., 2020, Clin Infect Dis
[10]   Defining the Epidemiology of Covid-19-Studies Needed [J].
Lipsitch, Marc ;
Swerdlow, David L. ;
Finelli, Lyn .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (13) :1194-1196