Effect of diallyl disulfide on acute gastric mucosal damage induced by alcohol in rats

被引：17

作者：

Lee, I-C ^{[1
]}

Baek, H-S ^{[1
]}

Kim, S-H ^{[1
]}

Moon, C. ^{[1
]}

Park, S-H ^{[1
]}

Kim, S-H ^{[1
]}

Shin, I-S ^{[1
,2
]}

Park, S-C ^{[3
]}

Kim, J-C ^{[1
]}

机构：

[1] Chonnam Natl Univ, Coll Vet Med, Kwangju 500757, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Nat Med Res Ctr, Chungbuk, South Korea

[3] Kyungpook Natl Univ, Coll Vet Med, Taegu, South Korea

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 2015年 / 34卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Ethanol; gastric mucosal damages; oxidative stress; diallyl disulfide; NITRIC-OXIDE; GARLIC OIL; ANTIULCEROGENIC ACTIVITY; ORGANOSULFUR COMPOUNDS; OXIDATIVE DAMAGE; ETHANOL; ULCER; EXTRACT; MECHANISM; PROSTAGLANDINS;

D O I：

10.1177/0960327114537095

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

This study investigated the gastroprotective effects of diallyl disulfide (DADS), a secondary organosulfur compound derived from garlic (Allium sativum L.) on experimental model of ethanol (EtOH)-induced gastric ulcer in rats. The antiulcerogenic activity of DADS was evaluated by gross/histopathological inspection, pro-inflammatory cytokines, and lipid peroxidation with antioxidant enzyme activities in the stomach. DADS (100 mg/kg) was administered by oral gavage 2 h prior to EtOH treatment (5 ml/kg). The animals were killed I h after receiving EtOH treatment. Pretreatment with DADS attenuated EtOH-induced gastric mucosal injury, as evidenced by decreased severity of hemorrhagic lesions and gastric ulcer index upon visual inspection. DADS also prevented histopathological alterations and gastric apoptotic changes caused by EtOH. An increase in tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase was observed in the gastric tissues of EtOH-treated rats that coincided with increased serum TNF-alpha and interleukin 6 levels. In contrast, DADS effectively suppressed production of pro-inflammatory mediators induced by EtOH. Furthermore, DADS prevented the formation of gastric malondialdehyde and the depletion of reduced glutathione content and restored antioxidant enzyme activities, such as catalase, glutathione peroxidase, and glutathione reductase in the gastric tissues of EtOH-treated rats. These results indicate that DADS prevents gastric mucosal damage induced by acute EtOH administration in rats and that the protective effects of DADS may be due to its potent antioxidant and anti-inflammatory activities.

引用

页码：227 / 239

页数：13

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