A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma

被引：110

作者：

Koehler, Jennifer W. ^{[1
]}

Miller, Andrew D. ^{[2
]}

Miller, C. Ryan ^{[3
,4
,5
]}

Porter, Brian ^{[6
]}

Aldape, Kenneth ^{[7
]}

Beck, Jessica ^{[8
]}

Brat, Daniel ^{[9
]}

Cornax, Ingrid ^{[10
]}

Corps, Kara ^{[11
]}

Frank, Chad ^{[12
]}

Giannini, Caterina ^{[13
]}

Horbinski, Craig ^{[14
,15
]}

Huse, Jason T. ^{[16
,17
]}

O'Sullivan, M. Gerard ^{[18
,19
]}

Rissi, Daniel R. ^{[20
,21
]}

Simpson, R. Mark ^{[22
]}

Woolard, Kevin ^{[23
]}

Shih, Joanna H. ^{[24
]}

Mazcko, Christina ^{[25
]}

Gilbert, Mark R. ^{[26
,27
]}

LeBlanc, Amy K. ^{[28
]}

机构：

[1] Auburn Univ, Coll Vet Med, Dept Pathobiol, Auburn, AL 36849 USA

[2] Cornell Univ, Coll Vet Med, Sect Anat Pathol, Dept Biomed Sci, Ithaca, NY 14853 USA

[3] Univ N Carolina, Sch Med, Dept Pharmacol & Lab Med, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA

[4] Univ N Carolina, Sch Med, Dept Neurol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA

[5] Univ N Carolina, Sch Med, Dept Pharmacol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA

[6] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Pathobiol, College Stn, TX USA

[7] NCI, Pathol Lab, Ctr Canc Res, NIH, Bldg 10, Bethesda, MD 20892 USA

[8] NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bldg 37, Bethesda, MD 20892 USA

[9] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA

[10] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA

[11] NINDS, NIH, Viral Immunol & Intravital Imaging Sect, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[12] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

[13] Mayo Clin, Div Anat Pathol, Dept Lab Med & Pathol, Coll Med, Rochester, MN USA

[14] Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA

[15] Northwestern Univ, Feinberg Sch Med, Dept Neurosurg, Chicago, IL 60611 USA

[16] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[17] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA

[18] Univ Minnesota, Coll Vet Med, Masonic Canc Ctr, Comparat Pathol Shared Resource, St Paul, MN 55108 USA

[19] Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN 55108 USA

[20] Univ Georgia, Coll Vet Med, Dept Pathol, Athens, GA 30602 USA

[21] Univ Georgia, Coll Vet Med, Athens Vet Diagnost Lab, Athens, GA USA

[22] NCI, Ctr Canc Res, NIH, Mol Pathol Unit,Lab Canc Biol & Genet, Bethesda, MD 20892 USA

[23] Univ Calif Davis, Dept Pathol Microbiol & Immunol, Sch Vet Med, Davis, CA 95616 USA

[24] NCI, Biometr Res Program, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA

[25] NCI, Comparat Oncol Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[26] Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA

[27] NCI, Ctr Canc Res, NIH, NeuroOncol Branch, Bethesda, MD 20892 USA

[28] NCI, NIH, Comparat Oncol Program, Ctr Canc Res, Bethesda, MD 20892 USA

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2018年 / 77卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Canine; Comparative; Glioma; MOLECULAR-GENETICS; BRAIN; TUMORS; DOGS; IMMUNOHISTOCHEMISTRY; OLIGODENDROGLIOMA; TRANSLATION; MUTATIONS; NEOPLASIA; PATHWAYS;

D O I：

10.1093/jnen/nly085

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The National Cancer Institute-led multidisciplinary Comparative Brain Tumor Consortium (CBTC) convened a glioma pathology hoard, comprising both veterinarian and physician neuropathologists, and conducted a comprehensive review of 193 cases of canine glioma. The immediate goal was to improve existing glioma classification methods through creation of a histologic atlas of features, thus yielding greater harmonization of phenotypic characterization. The long-term goal was to support future incorporation of clinical outcomes and genomic data into proposed simplified diagnostic schema, so as to further bridge the worlds of veterinary and physician neuropathology and strengthen validity of the dog as a naturally occurring, translationally relevant animal model of human glioma. All cases were morphologically reclassified according to a new schema devised by the entire board, yielding a majority opinion diagnosis of astrocytoma (43, 22.3%), 19 of which were low-grade and 24 high-grade, and oligodendroglioma (134, 69.4%), 35 of which were low-grade and 99 were high-grade. Sixteen cases (8.3%) could not be classified as oligodendroglioma or astrocytoma based on morphology alone and were designated as undefined gliomas. The simplified classification scheme proposed herein provides a tractable means for future addition of molecular data, and also serves to highlight histologic similarities and differences between human and canine glioma.

引用

页码：2018 / 1054

页数：16

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