Vaccines against respiratory syncytial virus: The time has finally come

被引:70
作者
Graham, Barney S. [1 ]
机构
[1] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
关键词
RSV; Immunization; Vaccination; Structure-based vaccine design; Fusion; Neutralization; Vaccine-enhanced illness; Bronchiolitis; Pneumonia; Infants; Elderly; Th2; Eosinophilia; Subunit vaccine; Vaccine vector; Wheezing; Asthma; Protein conformation; Epitope; FUSION GLYCOPROTEIN; STRUCTURAL-ANALYSIS; ANTIGENIC STRUCTURE; PRIMARY INFECTION; RSV INFECTION; DISEASE; INFANTS; IMMUNIZATION; PROTECTION; CHILDREN;
D O I
10.1016/j.vaccine.2016.04.083
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Respiratory syncytial virus causes a significant public health burden, particularly in very young infants and the frail elderly. The legacy of enhanced RSV disease (ERD) from a whole formalin-inactivated RSV vaccine, and the complex biology of the virus and the neonate have delayed the development of effective vaccines. However, new insights into factors associated with ERD and breakthroughs in understanding the antigenic structure of the fusion (F) glycoprotein have increased optimism that vaccine development is possible. This has led to investment of time and resources by industry, regulatory authorities, governments, and nonprofit organizations to develop the infrastructure needed to make the advanced clinical development of RSV vaccine candidates a reality. Published by Elsevier Ltd.
引用
收藏
页码:3535 / 3541
页数:7
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