Effects of ethanol on startle responding in alcohol-preferring and -non-preferring rats

被引:26
作者
Jones, AE
McBride, WJ
Murphy, JM
Lumeng, L
Li, TK
Shekhar, A
McKinzie, DL
机构
[1] Indiana Univ, Sch Med, Inst Psychiat Res, Program Med Neurobiol, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA
[3] Indiana Univ Purdue Univ, Purdue Sch Sci, Dept Psychol, Indianapolis, IN 46202 USA
[4] Indiana Univ, Sch Med, Dept Med & Biochem, Indianapolis, IN 46202 USA
[5] VA Med Ctr, Indianapolis, IN USA
[6] Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA
关键词
acoustic startle response; prepulse inhibition; alcohol-preferring P rats; alcohol-non-preferring NP rats; anxiety; sensorimotor gating;
D O I
10.1016/S0091-3057(00)00363-4
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The objectives of the present study were to determine (a) if differences exist between the selectively bred alcohol-preferring (P) and -nonpreferring (NP) lines of rats in the acoustic startle response (ASR) and prepulse inhibition (PPI), and (6) the effects of ethanol on these measures. Alcohol-naive adult female P and NP rats received a single i.p. injection of saline or ethanol (0.25, 0.5, 1.0, or 1.5 g/kg) and were placed in the startle apparatus 10 min later. After a 5-min acclimation period, rats received five alternating trials of a startle stimulus alone (SSA) (115-dB white noise) or a PPI trial (90-dB white noise preceding a 115-dB white noise). Analysis of the ASR revealed that P rats exhibited higher startle amplitudes than did NP rats with saline injections. The 0.5-g/kg ethanol dose reduced the startle amplitude in P, but not NP, rats. The 1.0- and 1.5-g/kg ethanol doses nearly abolished the ASR in the NP line, whereas only the highest ethanol dose had this effect in the P line. Vehicle-heated P and NP rats exhibited comparable PPI levels, but only P rats showed a significant disruption (30%) at the 0.50-g/kg ethanol dose. Neither P nor NP rats were affected by ethanol treatment at the 0.25-g/kg dose. Overall, the results suggest that: (a) the difference in baseline ASR may indicate line differences in the neurocircuitry mediating this response, possibly reflecting higher innate levels of emotional reactivity in the P line; (b) the P line may be more sensitive than the NP line to the effects of ethanol in reducing emotional reactivity; and (c) low-dose ethanol may have a greater disruptive effect on sensorimotor gating mechanisms in the P than NP rat. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:313 / 318
页数:6
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