In vitro anti-malarial activity of 20 quinones isolated from four plants used by traditional healers in the Democratic Republic of Congo

被引：0
|
作者：
Kayembe, J. S. [1 ]
Taba, K. M. [1 ]
Ntumba, K. [1 ]
Tshiongo, M. T. C. [1 ]
Kazadi, T. K. [1 ]
机构：
[1] Univ Kinshasa, Fac Sci, Dept Chem, Kinshasa XI, DEM REP CONGO
来源：
JOURNAL OF MEDICINAL PLANTS RESEARCH | 2010年 / 4卷 / 11期
关键词：
Cassia alata; Cassia occidentalis; Garcinia kola; Ocimum basilicum; quinones; anti-malarial activity; in vitro; CASSIA-OCCIDENTALIS; EXTRACTS; MALARIA; ATOVAQUONE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The anti-malarial activity of 20 quinones isolated from Cassia alata, Cassia occidentalis, Garcinia kola and Ocimum basilicum was investigated in vitro using the micro dilution test of Desjardin by a visual evaluation on thin blood smears. The six quinones isolated from C. occidentalis, three from C. alata and three from O. basilicum were found to be the most active with an IC50 value of below 1 mu g/ml. The others quinones showed a moderate activity with IC50 values of between 5 and 20 mu g/ml.
引用
收藏
页码：991 / 994
页数：4
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