Silver nanoparticles impede the biofilm formation by Pseudomonas aeruginosa and Staphylococcus epidermidis

被引:541
作者
Kalishwaralal, Kalimuthu [1 ]
BarathManiKanth, Selvaraj [1 ]
Pandian, Sureshbabu Ram Kumar [1 ]
Deepak, Venkataraman [1 ]
Gurunathan, Sangiliyandi [1 ]
机构
[1] Kalasalingam Univ, Div Mol & Cellular Biol, Dept Biotechnol, Krishnankoil 626190, Tamil Nadu, India
关键词
Anti-biofilm activity; Silver nanoparticles; Keratitis; Pseudomonas aeruginosa; Staphylococcus epidermidis; COAGULASE-NEGATIVE STAPHYLOCOCCI; MICROBIAL KERATITIS; CONTACT-LENSES; ADHESION; HYDROGEL; MODEL;
D O I
10.1016/j.colsurfb.2010.04.014
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Biofilms are ensued due to bacteria that attach to surfaces and aggregate in a hydrated polymeric matrix. Formation of these sessile communities and their inherent resistance to anti-microbial agents are the source of many relentless and chronic bacterial infections. Such biofilms are responsible play a major role in development of ocular related infectious diseases in human namely microbial keratitis. Different approaches have been used for preventing biofilm related infections in health care settings. Many of these methods have their own demerits that include chemical based complications: emergent antibiotic resistant strains, etc. silver nanoparticles are renowned for their influential anti-microbial activity. Hence the present study over the biologically synthesized silver nanoparticles, exhibited a potential anti-biofilm activity that was tested in vitro on biofilms formed by Pseudomonas aeruginosa and Staphylococcus epidermidis during 24-h treatment. Treating these organisms with silver nanoparticles resulted in more than 95% inhibition in biofilm formation. The inhibition was known to be invariable of the species tested. As a result this study demonstrates the futuristic application of silver nanoparticles in treating microbial keratitis based on its potential anti-biofilm activity. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:340 / 344
页数:5
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