Bacterial lipopolysaccharide shifts fasted plasma ghrelin to postprandial levels in rats

被引：68
作者：
Basa, NR
Wang, LX
Arteaga, JR
Heber, D
Livingston, EH
Taché, Y
机构：
[1] Univ Calif Los Angeles, CURE, Dept Med,David Geffen Sch Med, Digest Dis Res Ctr,Digest Dis Div,VAGLAHS, Los Angeles, CA 90073 USA
[2] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90073 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Human Nutr, Los Angeles, CA 90073 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, VA Greater Los Angeles Healthcare Syst, Dept Surg, Los Angeles, CA 90073 USA
来源：
NEUROSCIENCE LETTERS | 2003年 / 343卷 / 01期
关键词：
lipopolysaccharide; circulating ghrelin; food intake; rat; rectal temperature; LPS-INDUCED ANOREXIA; ENDOTOXIN; INSULIN; EXPRESSION;
D O I：
10.1016/S0304-3940(03)00312-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Lipopolysaccharide (LPS) injected intraperitoneally (i.p.) is known to decrease food intake. Ghrelin is a peptide hormone produced by the stomach with a potent orexigenic effect and plasma levels that are inversely correlated with the fed state. We examined changes in plasma ghrelin levels 3 h after LPS (100 mug/kg, i.p.) in fasted rats with or without a 1 h re-feeding period. LPS injection decreased the fasting levels of ghrelin by 51 +/- 5% compared with preinjection values while i.p. vehicle did not modify ghrelin levels in fasted rats. LPS at this dose reduced fasting-induced food intake by 60% compared with the i.p. vehicle group. Re-feeding decreased plasma ghrelin levels by 58 +/- 3% compared with pre-feeding fasting values in i.p. vehicle group. These data provide the first evidence that LPS shifts fasting ghrelin levels to those observed postprandially. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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页码：25 / 28
页数：4
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