Amphiphilic PEG-b-PMCL-b-PDMAEMA Triblock Copolymers: From Synthesis to Physico-Chemistry of Self-Assembled Structures

被引：20

作者：

Matter, Yves ^{[1
]}

Enea, Ramona ^{[1
]}

Casse, Olivier ^{[1
]}

Lee, Cameron C. ^{[2
]}

Baryza, Jeremy ^{[2
]}

Meier, Wolfgang ^{[1
]}

机构：

[1] Univ Basel, Dept Phys Chem, CH-4056 Basel, Switzerland

[2] Novartis Inst Biomed Res, Cambridge, MA 02139 USA

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 2011年 / 212卷 / 09期

关键词：

ATRP; light scattering; methylcaprolactone; self assembly; triblock copolymers; EPSILON-CAPROLACTONE; DRUG-DELIVERY; POLY(ETHYLENE GLYCOL); BLOCK-COPOLYMERS; AQUEOUS-SOLUTION; RADICAL POLYMERIZATION; DIBLOCK COPOLYMERS; ETHYLENE-OXIDE; GENE DELIVERY; IN-VIVO;

D O I：

10.1002/macp.201000661

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A synthetic route toward a new family of amphiphilic mPEG-b-PMCL-b-PDMAEMA triblock copolymers is reported. Chemical structures and compositions are confirmed by (1)H NMR and SEC. Polydispersity indices are typically <1.4, indicating good control of the reactions. The physicochemical parameters associated with mPEG-b-PMCL-b-PDMAEMA self-assembled structures are investigated. Nanoparticles are prepared via a co-solvent method, and parameters such as nanoparticle <(M)over bar>(w), N(agg), A(2), and R(h) are calculated based on static and dynamic light scattering data. Critical aggregation concentrations for the polymers are determined by measuring surface tensions of polymer solutions. TEM is employed to visualize the morphology of the assemblies.

引用

页码：937 / 949

页数：13

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