Interactions between HLA-G and HLA-E in physiological and pathological conditions

被引：74

作者：

Morandi, Fabio ^{[1
]}

Pistoia, Vito ^{[1
]}

机构：

[1] Ist Giannina Gaslini, Lab Oncol, I-16148 Genoa, Italy

来源：

FRONTIERS IN IMMUNOLOGY | 2014年 / 5卷

关键词：

HLA-G; HLA-E; tumor; autoimmune disease; viral infections; CD4(+) T-CELLS; MESENCHYMAL STEM-CELLS; CLASS-I MOLECULES; DENDRITIC CELLS; SURFACE EXPRESSION; IMMUNE PRIVILEGE; CANCER PATIENTS; TUMOR-CELLS; IFN-GAMMA; ANTIGEN;

D O I：

10.3389/fimmu.2014.00394

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HLA-G and HLA-E are immunoregulatory molecules that belong to HLA-lb family. The role of these molecules in the control of the immune response has been extensively analyzed, both in physiological and pathological conditions. We have here summarized data present in the literature regarding the interaction of these molecules in different settings. These data suggested that HLA-G and -E co-operate in physiological conditions (i.e., establishment of an immune tolerance at maternal/fetal interface during pregnancy), whereas their role in the course of tumors or autoimmune/inflammatory diseases may be different or even opposite. Future studies aimed at investigating the interaction between HLA-G and HLA-E will help to clarify mechanism(s) underlying the regulation of immune effector cells in health and disease.

引用

页码：1 / 6

页数：6

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