BIOMATERIAL BASED INJECTABLE HYDROGEL FOR CONTROLLED DRUG DELIVERY: A REVIEW

The aim of a pharmaceutical product is to obtain excellent therapeutic and favorable treatment. Controlled drug release coatings have been around for more than 50 years and their performance has increased significantly since the beginning. The main drawbacks of the controlled drug delivery system are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. To overcome this disadvantage, the researcher focused on controlled drug delivery system Injectable hydrogels. It is an emerging trend in the field of biomaterial drug delivery systems. Injectable Hydrogel overcomes the limitation of a pre-formed hydrogel, as they are injected with minimum invasive procedure into target sites and used for irregularly shaped sites. The recent studies of injectable hydrogels for the drug delivery applications suggested that multi-functional injectable hydrogels are capable of entrapping and systematically delivering the multiple therapeutic agents like drugs and macromolecules. The Injectable hydrogel shows shear thinning property when injected into the body. In this review, various aspects of Injectable hydrogel like introduction, Properties, preparation methods, drug loading and drug release strategies and applications of injectable hydrogels were discussed.