One pot kinetic resolution and product separation with corn germ oil and supercritical carbon dioxide

被引：6

作者：

Kmecz, Ildiko ^{[1
]}

Varga, Zsofia ^{[1
]}

Szekely, Edit ^{[1
]}

机构：

[1] Budapest Univ Technol & Econ, Dept Chem & Environm Proc Engn, Muegyet Rkp 3, Budapest, Hungary

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2018年 / 141卷

关键词：

Lipase; Selective separation; Fatty acid esters; Enzyme; Gas chromatography; Process development; IMMOBILIZED LIPASE; SECONDARY ALCOHOLS; ESTERS; ACID; (R; S)-1-PHENYLETHANOL; ESTERIFICATION; EQUILIBRIA; SOLVENT; MODEL;

D O I：

10.1016/j.supflu.2018.01.014

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Enantioseparation of 1-phenylethanol with corn germ oil, obtained by supercritical carbon dioxide, is efficiently catalysed by Novozyme 435. The reaction has high enantioselectivity (E > 1000) and the equilibrium conversion is approx. 90% at 50 degrees C both at ambient pressure and at 20 MPa. The esters and the remaining alcohol can be separated by supercritical carbon dioxide extraction and sequential pressure drop using a pressurized and an atmospheric separator. The determination of suitable pressure and temperature conditions were supported by phase equilibria measurements and distribution ratio determination.

引用

页码：218 / 223

页数：6

共 31 条

[1] Vapor-liquid equilibria of carbon dioxide with linoleic acid, α-tocopherol and triolein at elevated pressures [J].

Chen, CC ;

Chang, CMJ ;

Yang, PW .

FLUID PHASE EQUILIBRIA, 2000, 175 (1-2) :107-115

[2] Lipase-mediated enantioselective acylation of alcohols with functionalized vinyl esters: acyl donor tolerance and applications [J].

Chenevert, Robert ;

Pelchat, Nicholas ;

Morin, Pierre .

TETRAHEDRON-ASYMMETRY, 2009, 20 (10) :1191-1196

[3] Effect of solvent and initial water content on (R, S)-1-phenylethanol resolution [J].

Chua, LS ;

Sarmidi, MR .

ENZYME AND MICROBIAL TECHNOLOGY, 2006, 38 (3-4) :551-556

[4]

Chua LS, 2010, IJEE, V1, P234

[5] KINETIC-STUDY OF ESTERIFICATION BY IMMOBILIZED LIPASE IN N-HEXANE [J].

CHULALAKSANANUKUL, W ;

CONDORET, JS ;

DELORME, P ;

WILLEMOT, RM .

FEBS LETTERS, 1990, 276 (1-2) :181-184

[6] Continuous biocatalytic conversion of the oil of corn distiller's dried grains with solubles to fatty acid methyl esters in supercritical carbon dioxide [J].

Ciftci, Ozan Nazim ;

Temelli, Feral .

BIOMASS & BIOENERGY, 2013, 54 :140-146

[7] Lipase catalyse glycerolysis for kinetic resolution of racemates [J].

Dlugy, C. ;

Wolfson, A. .

BIOPROCESS AND BIOSYSTEMS ENGINEERING, 2007, 30 (05) :327-330

[8] Kinetic resolution of 1-phenyl ethanol with high enantioselectivity with native and immobilized lipase in organic solvents [J].

Frings, K ;

Koch, M ;

Hartmeier, W .

ENZYME AND MICROBIAL TECHNOLOGY, 1999, 25 (3-5) :303-309

[9] Phase equilibrium properties of the 1-phenylethanol-carbon dioxide and 2-octanol-carbon dioxide binary systems at 303.15 K, 313.15 K, and 323.15. K [J].

Gamse, T ;

Marr, R .

JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2001, 46 (01) :117-119

[10] Kinetic model for the esterification of oleic acid and cetyl alcohol using an immobilized lipase as catalyst [J].

Garcia, T ;

Coteron, A ;

Martinez, M ;

Aracil, J .

CHEMICAL ENGINEERING SCIENCE, 2000, 55 (08) :1411-1423

← 1 2 3 4 →