Basal Cortisol Levels Are Increased in Patients with Mild Cognitive Impairment: Role of Insomnia and Short Sleep Duration

被引:14
作者
Basta, Maria [1 ,2 ]
Vgontzas, Alexandros N. [1 ,2 ]
Fernandez-Mendoza, Julio [2 ]
Antypa, Despina [1 ]
Li, Yun [3 ,4 ]
Zaganas, Ioannis [5 ]
Panagiotakis, Symeon [6 ]
Karagkouni, Efthalia [2 ]
Simos, Panagiotis [1 ,7 ]
机构
[1] Univ Hosp Heraklion, Dept Psychiat, Iraklion, Crete, Greece
[2] Penn State Univ, Sleep Res & Treatment Ctr, Dept Psychiat, Hershey, PA 17033 USA
[3] Shantou Univ, Dept Sleep Med, Mental Hlth Ctr, Shantou, Guangdong, Peoples R China
[4] Shantou Univ, Sleep Med Ctr, Med Coll, Shantou, Guangdong, Peoples R China
[5] Univ Hosp Heraklion, Dept Neurol, Iraklion, Crete, Greece
[6] Univ Hosp Heraklion, Dept Internal Med, Iraklion, Crete, Greece
[7] Fdn Res & Technol Hellas, Inst Comp Sci, Computat Biomed Lab, Iraklion, Greece
关键词
Cortisol; insomnia; mild cognitive impairment; sleep duration; PITUITARY-ADRENAL AXIS; SALIVARY CORTISOL; STRESS; ASSOCIATION; DECLINE; DISEASE; LIFE; SECRETION; QUALITY; BRAIN;
D O I
10.3233/JAD-215523
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Mild cognitive impairment (MCI) is frequent in elderly and a risk factor for dementia. Both insomnia and increased cortisol levels are risk factors for MCI. Objective: We examined cross-sectionally whether increased cortisol levels are associated with short sleep duration (SSD) and/or the insomnia short sleep duration (ISS) phenotype, in elderly with MCI. Methods: One hundred twenty-four participants with MCI and 84 cognitively non-impaired controls (CNI)=60 years underwent medical history, physical examination, neuropsychiatric evaluation, neuropsychological testing, 3-day actigraphy, assessment of subjective insomnia symptoms, and a single morning plasma cortisol level. The short sleep phenotypes were defined by sleep efficiency below the median of the entire sample (i.e.,<= 81%) with at least one insomnia symptom (ISS) or without (SSD). ANOVA models were used to compare the various sleep phenotypes to those who did not present either short sleep or insomnia symptoms [non-insomnia (NI)]. Results: MCI participants had higher cortisol levels compared to the CNI group (p = 0.009). MCI participants with insomnia (n = 44) or SSD (n = 38) had higher cortisol levels compared to the NI group (n = 42; p = 0.014 and p = 0.045, respectively). Furthermore, MCI participants with ISS phenotype but not those with insomnia with normal sleep duration had higher cortisol levels compared to NI (p = 0.011 and p = 0.4, respectively). Both linear trend analyses showed that cortisol reached the highest levels in the ISS phenotype. Conclusion: The ISS and SSD phenotypes are associated with increased cortisol levels in elderly with MCI. Improving sleep quality and duration and decreasing cortisol levels may delay further cognitive decline.
引用
收藏
页码:933 / 944
页数:12
相关论文
共 63 条
[1]   Objective short sleep duration and 24-hour blood pressure [J].
Abdalla, Marwah ;
Schwartz, Joseph E. ;
Cornelius, Talea ;
Chang, Bernard P. ;
Alcantara, Carmela ;
Shechter, Ari .
INTERNATIONAL JOURNAL CARDIOLOGY HYPERTENSION, 2020, 7
[2]  
[Anonymous], US RANKED 1 POPULATI
[3]   Stress signalling pathways that impair prefrontal cortex structure and function [J].
Arnsten, Amy F. T. .
NATURE REVIEWS NEUROSCIENCE, 2009, 10 (06) :410-422
[4]   Seasonal effects on cortisol secretion in normal aging, mild cognitive impairment and Alzheimer's disease [J].
Arsenault-Lapierre, Genevieve ;
Chertkow, Howard ;
Lupien, Sonia .
NEUROBIOLOGY OF AGING, 2010, 31 (06) :1051-1054
[5]   Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype [J].
Baril, Andree-Ann ;
Beiser, Alexa S. ;
Sanchez, Erlan ;
Mysliwiec, Vincent ;
Redline, Susan ;
Gottlieb, Daniel J. ;
O'Connor, George T. ;
Gonzales, Mitzi M. ;
Himali, Dibya ;
Seshadri, Sudha ;
Himali, Jayandra J. ;
Pase, Matthew P. .
ALZHEIMERS & DEMENTIA, 2022, 18 (03) :408-421
[6]   Objective Daytime Napping is Associated with Disease Severity and Inflammation in Patients with Mild to Moderate Dementia [J].
Basta, Maria ;
Koutentaki, Eirini ;
Vgontzas, Alexandros ;
Zaganas, Ioannis ;
Vogiatzi, Emmanouela ;
Gouna, Garyfalia ;
Bourbouli, Mara ;
Panagiotakis, Symeon ;
Kapetanaki, Stefania ;
Fernandez-Mendoza, Julio ;
Simos, Panagiotis .
JOURNAL OF ALZHEIMERS DISEASE, 2020, 74 (03) :803-815
[7]   Associations between sleep duration and cognitive impairment in mild cognitive impairment [J].
Basta, Maria ;
Simos, Panagiotis ;
Vgontzas, Alexandros ;
Koutentaki, Eirini ;
Tziraki, Sophia ;
Zaganas, Ioannis ;
Panagiotakis, Symeon ;
Kapetanaki, Stefania ;
Fountoulakis, Nikolaos ;
Lionis, Christos .
JOURNAL OF SLEEP RESEARCH, 2019, 28 (06)
[8]   Association between insomnia symptoms and cognitive impairment in the Cretan Aging Cohort [J].
Basta, Maria ;
Simos, Panagiotis ;
Bertsias, Antonios ;
Duijker, George ;
Zaganas, Ioannis ;
Koutentaki, Eirini ;
Anastasaki, Maria ;
Mavroidis, Giorgos ;
Kalomoiri, Georgia ;
Panagiotakis, Symeon ;
Lionis, Christos ;
Vgontzas, Alexandros .
EUROPEAN GERIATRIC MEDICINE, 2018, 9 (05) :697-706
[9]   Effects of age on sleep apnea in men I. Prevalence and severity [J].
Bixler, EO ;
Vgontzas, AN ;
Ten Have, T ;
Tyson, K ;
Kales, A .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (01) :144-148
[10]   Insomnia in Central Pennsylvania [J].
Bixler, EO ;
Vgontzas, AN ;
Lin, HM ;
Vela-Bueno, A ;
Kales, A .
JOURNAL OF PSYCHOSOMATIC RESEARCH, 2002, 53 (01) :589-592