Gene therapy of arthritis

被引：2
作者：
Nepomnyashchikh, T. S. [1 ]
Antonets, D. V. [1 ]
Shchelkunov, S. N. [1 ]
机构：
[1] State Res Ctr Virusol & Biotechnol Vector, Novosibirsk 630559, Koltsovo, Russia
来源：
RUSSIAN JOURNAL OF GENETICS | 2016年 / 52卷 / 06期
基金：
俄罗斯基础研究基金会; 俄罗斯科学基金会;
关键词：
gene therapy; arthritis; cytokines; cytokine antagonists; COLLAGEN-INDUCED ARTHRITIS; TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1; RECEPTOR-ANTAGONIST; RECOMBINANT ADENOASSOCIATED VECTOR; ADENOVIRUS-MEDIATED TRANSFER; IL-18; BINDING-PROTEIN; SOLUBLE TNF RECEPTOR; II-INDUCED ARTHRITIS; REACTIVE T-CELLS; RHEUMATOID-ARTHRITIS;
D O I：
10.1134/S1022795416050094
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Gene therapy can offer a new approach to arthritis treatment which acts at an inflammation site. Numerous studies show high efficacy of gene therapy in different models of arthritis in humans. Even a single injection of a recombinant vector results in a stable prolonged expression of a therapeutic gene and a longterm therapeutic effect. In contrast to biologic therapy involving numerous systemic injections of recombinant anti-inflammatory proteins, gene therapy does not produce systemic side effects. Vectors based on retroviruses, adenoviruses, adeno-associated viruses, and recombinant plasmids could provide delivery of target genes. Of significant importance is the development of noninvasive methods of gene therapy: intranasal and peroral. The current state of research in arthritis gene therapy is discussed in this review.
引用
收藏
页码：543 / 556
页数：14
相关论文
共 173 条
  • [41] Furuzawa-Carballeda J, 2008, CLIN EXP RHEUMATOL, V26, P554
  • [42] Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor α soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects
    Ghivizzani, SC
    Lechman, ER
    Kang, R
    Tio, C
    Kolls, J
    Evans, CH
    Robbins, PD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (08) : 4613 - 4618
  • [43] Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: Implications for arthritis gene therapy
    Ghivizzani, SC
    Lechman, ER
    Tio, C
    Mule, KM
    Chada, S
    McCormack, JE
    Evans, CH
    Robbins, PD
    [J]. GENE THERAPY, 1997, 4 (09) : 977 - 982
  • [44] Recombinant TNF-binding protein from variola virus as a novel potential TNF antagonist
    Gileva, I. P.
    Nepomnyashchikh, T. S.
    Ryazankin, I. A.
    Shchelkunov, S. N.
    [J]. BIOCHEMISTRY-MOSCOW, 2009, 74 (12) : 1356 - 1362
  • [45] Expression of genes for orthopoxviral TNF-binding proteins in insect cells and investigation of the recombinant TNF-binding proteins
    Gileva, IP
    Ryazankin, IA
    Nepomnyashchikh, TS
    Totmenin, AV
    Maxutov, ZA
    Lebedev, LR
    Afinogenova, GN
    Pustoshilova, NM
    Shchelkunov, SN
    [J]. MOLECULAR BIOLOGY, 2005, 39 (02) : 218 - 225
  • [46] GILEVA IP, 2006, CITOKINY VOSPALENIE, V1, P44
  • [47] Properties of the recombinant TNF-binding proteins from variola, monkeypox, and cowpox viruses are different
    Gileva, Irina P.
    Nepomnyashchikh, Tatiana S.
    Antonets, Denis V.
    Lebedev, Leonid R.
    Kochneva, Galina V.
    Grazhdantseva, Antonina V.
    Shchelkunov, Sergei N.
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2006, 1764 (11): : 1710 - 1718
  • [48] Tolerance Induction Using Lentiviral Gene Delivery Delays Onset and Severity of Collagen II Arthritis
    Gjertsson, Inger
    Laurie, Karen L.
    Devitt, James
    Howe, Steven J.
    Thrasher, Adrian J.
    Holmdahl, Rikard
    Gustafsson, Kenth
    [J]. MOLECULAR THERAPY, 2009, 17 (04) : 632 - 640
  • [49] Goossens PH, 2001, ARTHRITIS RHEUM, V44, P48, DOI 10.1002/1529-0131(200101)44:1<48::AID-ANR7>3.0.CO
  • [50] 2-D
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