Gene therapy of arthritis

被引：2
作者：
Nepomnyashchikh, T. S. [1 ]
Antonets, D. V. [1 ]
Shchelkunov, S. N. [1 ]
机构：
[1] State Res Ctr Virusol & Biotechnol Vector, Novosibirsk 630559, Koltsovo, Russia
来源：
RUSSIAN JOURNAL OF GENETICS | 2016年 / 52卷 / 06期
基金：
俄罗斯基础研究基金会; 俄罗斯科学基金会;
关键词：
gene therapy; arthritis; cytokines; cytokine antagonists; COLLAGEN-INDUCED ARTHRITIS; TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1; RECEPTOR-ANTAGONIST; RECOMBINANT ADENOASSOCIATED VECTOR; ADENOVIRUS-MEDIATED TRANSFER; IL-18; BINDING-PROTEIN; SOLUBLE TNF RECEPTOR; II-INDUCED ARTHRITIS; REACTIVE T-CELLS; RHEUMATOID-ARTHRITIS;
D O I：
10.1134/S1022795416050094
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Gene therapy can offer a new approach to arthritis treatment which acts at an inflammation site. Numerous studies show high efficacy of gene therapy in different models of arthritis in humans. Even a single injection of a recombinant vector results in a stable prolonged expression of a therapeutic gene and a longterm therapeutic effect. In contrast to biologic therapy involving numerous systemic injections of recombinant anti-inflammatory proteins, gene therapy does not produce systemic side effects. Vectors based on retroviruses, adenoviruses, adeno-associated viruses, and recombinant plasmids could provide delivery of target genes. Of significant importance is the development of noninvasive methods of gene therapy: intranasal and peroral. The current state of research in arthritis gene therapy is discussed in this review.
引用
收藏
页码：543 / 556
页数：14
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