Understanding the tumor microenvironment in head and neck squamous cell carcinoma

被引：22

作者：

Rad, Habib Sadeghi ^{[1
]}

Shiravand, Yavar ^{[2
]}

Radfar, Payar ^{[3
]}

Ladwa, Rahul ^{[1
,4
]}

Perry, Chris ^{[1
,4
]}

Han, Xiaoyuan ^{[5
]}

Warkiani, Majid Ebrahimi ^{[3
,6
]}

Adams, Mark N. ^{[7
]}

Hughes, Brett G. M. ^{[1
,8
]}

O'Byrne, Ken ^{[4
,7
]}

Kulasinghe, Arutha ^{[1
]}

机构：

[1] Univ Queensland, Univ Queensland Diamantina Inst, Brisbane, Qld, Australia

[2] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Naples, Italy

[3] Univ Technol Sydney, Sch Biomed Engn, Sydney, NSW, Australia

[4] Princess Alexandra Hosp, Brisbane, Qld, Australia

[5] Univ Pacific, Arthur A Dugoni Sch Dent, Dept Biomed Sci, Stockton, CA USA

[6] Sechenov First Moscow State Univ, Inst Mol Med, Moscow, Russia

[7] Queensland Univ Technol, Ctr Genom & Personalised Hlth, Sch Biomed Sci, Brisbane, Qld, Australia

[8] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia

来源：

CLINICAL & TRANSLATIONAL IMMUNOLOGY | 2022年 / 11卷 / 06期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

biomarkers; head and neck squamous cell carcinoma; human papillomavirus; immune checkpoint inhibitors; immunotherapy; tumor microenvironment; CTLA-4; BLOCKADE; INFILTRATING LYMPHOCYTES; ANTI-PD-L1; ANTIBODY; RADIATION-THERAPY; PD-1; NEO-ANTIGENS; CANCER; DIFFERENTIATION; IMMUNOTHERAPY; APOPTOSIS;

D O I：

10.1002/cti2.1397

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Head and neck squamous cell carcinoma (HNSCC) represents a heterogeneous group of tumors. While significant progress has been made using multimodal treatment, the 5-year survival remains at 50%. Developing effective therapies, such as immunotherapy, will likely lead to better treatment of primary and metastatic disease. However, not all HNSCC tumors respond to immune checkpoint blockade therapy. Understanding the complex cellular composition and interactions of the tumor microenvironment is likely to lead to new knowledge for effective therapies and treatment resistance. In this review, we discuss HNSCC characteristics, predictive biomarkers, factors influencing immunotherapy response, with a focus on the tumor microenvironment.

引用

页数：14

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