NF-κB: Much Learned, Much to Learn

被引：15

作者：

Razani, Bahram ^{[1
,2
]}

Cheng, Genhong ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Microbiol Immunol & Molec Genet, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Med Scientist Training Program, Ctr Hlth Sci 23-385, Los Angeles, CA 90095 USA

来源：

SCIENCE SIGNALING | 2010年 / 3卷 / 138期

关键词：

ACTIVATION; PATHWAYS;

D O I：

10.1126/scisignal.3138pe29

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although NF-kappa B (nuclear factor kappa B) was discovered less than 25 years ago, it is one of the most well-studied transcription factors. It plays critical roles in various immune and cellular processes, and its dysregulation is a major driver of cancer and inflammatory pathology. A new book published by Cold Spring Harbor Laboratory Press, NF-kappa B: A Network Hub Controlling Immunity, Inflammation, and Cancer, provides a series of excellent reviews on the architecture, regulation, and pathophysiological roles of NF-kappa B signaling by some of the leading investigators in the field.

引用

页数：4

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