INTEGRATIVE MOLECULAR CHARACTERIZATION OF HEAD AND NECK CANCER CELL MODEL GENOMES

被引：11

作者：

Tsui, Ivy F. L. ^{[1
,2
,3
]}

Garnis, Cathie ^{[1
,4
]}

机构：

[1] British Columbia Canc Res Ctr, Dept Canc Genet & Dev Biol, Vancouver, BC V5Z 1L3, Canada

[2] Univ British Columbia, Dept Pathol, Vancouver, BC, Canada

[3] Univ British Columbia, Dept Lab Med, Vancouver, BC V5Z 1M9, Canada

[4] Univ British Columbia, Dept Surg, Vancouver, BC V6T 1W5, Canada

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2010年 / 32卷 / 09期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

oral cancer; head and neck cancer; cell models; copy number alteration; RNA expression alteration; COPY NUMBER; 11Q13; AMPLICON; HIGH-FREQUENCY; ORAL-CANCER; LINES; GENE; CARCINOMA; AMPLIFICATION; IDENTIFICATION; ESTABLISHMENT;

D O I：

10.1002/hed.21311

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Cell lines are invaluable model systems for the investigation of cancer. Knowledge of the molecular alterations that exist within cell models is required to define the mechanisms governing cellular phenotypes. Methods. Five tongue squamous cell carcinomas cell lines and 1 submaxillary salivary gland epidermoid carcinoma cell line were analyzed for copy number and mRNA expression by tiling-path DNA microarrays and Agilent Whole Human Genome Oligoarrays, respectively. Results. Integrative analysis of genetic and expression alterations revealed the molecular landscape of each cell line. Molecular results for individual cell lines and across all samples have been summarized and made available for easy reference. Conclusion. Our integrative genomic analyses have defined the DNA and RNA alterations for each individual line. These data will be useful to anyone modeling oral cancer behavior, providing a molecular context that will be useful for deciphering cell phenotypes. (c) 2009 Wiley Periodicals, Inc. Head Neck 32: 1143-1160, 2010

引用

页码：1143 / 1160

页数：18

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