Clinical features and mortality in patients with early-onset Alzheimer's disease

被引：52
|
作者：
Samson, NW [1 ]
vanDuijn, CM [1 ]
Hop, WCJ [1 ]
Hofman, A [1 ]
机构：
[1] ERASMUS UNIV ROTTERDAM,SCH MED,DEPT EPIDEMIOL & BIOSTAT,3000 DR ROTTERDAM,NETHERLANDS
来源：
EUROPEAN NEUROLOGY | 1996年 / 36卷 / 02期
关键词：
Alzheimer's disease; prognosis; epidemiology;
D O I：
10.1159/000117218
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In a population-based study of 198 patients with probable early-onset Alzheimer's disease (AD), we studied the occurrence of extrapyramidal signs (tremors and rigidity), myoclonus, psychosis and seizures, as well as their predictive value for mortality. The presence of tremors was significantly associated with the presence of rigidity. The occurrence of myoclonus was significantly associated with the occurrence of seizures. Psychosis and seizures in AD patients were not associated with mortality. The occurrence of extrapyramidal signs and myoclonus at any point in time during the course of AD increased the risk of mortality significantly. When evaluating their relative importance, extrapyramidal signs appeared to be the most important predictor of mortality.
引用
收藏
页码：103 / 106
页数：4
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