Analysis of mammographic density and breast cancer risk from digitized mammograms

被引:204
作者
Byng, JW
Yaffe, MJ
Jong, RA
Shumak, RS
Lockwood, GA
Tritchler, DL
Boyd, NF
机构
[1] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada
[2] Mt Sinai Hosp, Dept Radiol, Toronto, ON M5G 1X5, Canada
[3] Univ Toronto, Ontario Canc Inst, Div Epidemiol & Stat, Toronto, ON, Canada
关键词
breast; parenchymal pattern; breast neoplasms; diagnosis; breast radiography; technology; cancer screening; computers; diagnostic aid;
D O I
10.1148/radiographics.18.6.9821201
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To evaluate the association between mammographic density and breast cancer risk, a simple, observer-assisted technique called interactive thresholding was developed that allows reliable quantitative assessment of mammographic density with use of a computer workstation Use of this technique helps con firm that mammographic density is one of the strongest risk factors for breast cancer and is present in a large proportion of breast cancer cases. The strong relationship between mammographic density and breast cancer risk suggests that the causes of breast cancer may be better understood by identifying the factors associated with mammographically dense tissue and determining how such tissue changes as these factors vary, Furthermore, because it can be modified, mammographic density may also be a good vehicle for the development and monitoring of potential preventive strategies, Areas of ongoing investigation include evaluating a potential genetic component of mammographic density by comparing density measurements in twins and understanding changes in density relative to age, menopausal status, exogenous hormone use, and exposure to environmental carcinogens. In addition, work is ongoing to establish measurements from imaging modalities other than mammography and to relate these measurements directly to breast cancer risk.
引用
收藏
页码:1587 / 1598
页数:12
相关论文
共 48 条
[1]  
Alberg Anthony J., 1997, Current Opinion in Oncology, V9, P505, DOI 10.1097/00001622-199711000-00003
[2]   PARENCHYMAL PATTERNS OF THE BREAST DEFINED BY REAL-TIME ULTRASOUND [J].
BLEND, R ;
RIDEOUT, DF ;
KAIZER, L ;
SHANNON, P ;
TUDORROBERTS, B ;
BOYD, NF .
EUROPEAN JOURNAL OF CANCER PREVENTION, 1995, 4 (04) :293-298
[3]  
BOYD NF, 1995, CANCER EPIDEM BIOMAR, V4, P727
[4]   Effects at two years of a low-fat, high-carbohydrate diet on radiologic features of the breast: Results from a randomized trial [J].
Boyd, NF ;
Greenberg, C ;
Lockwood, G ;
Little, L ;
Martin, L ;
Byng, J ;
Yaffe, M ;
Tritchler, D .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (07) :488-496
[5]   RELATIONSHIP BETWEEN MAMMOGRAPHIC AND HISTOLOGICAL RISK-FACTORS FOR BREAST-CANCER [J].
BOYD, NF ;
JENSEN, HM ;
COOKE, G ;
HAN, HL .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1992, 84 (15) :1170-1179
[6]   QUANTITATIVE CLASSIFICATION OF MAMMOGRAPHIC DENSITIES AND BREAST-CANCER RISK - RESULTS FROM THE CANADIAN NATIONAL BREAST SCREENING STUDY [J].
BOYD, NF ;
BYNG, JW ;
JONG, RA ;
FISHELL, EK ;
LITTLE, LE ;
MILLER, AB ;
LOCKWOOD, GA ;
TRITCHLER, DL ;
YAFFE, MJ .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (09) :670-675
[7]   MAMMOGRAPHIC SIGNS AS RISK-FACTORS FOR BREAST-CANCER [J].
BOYD, NF ;
OSULLIVAN, B ;
CAMPBELL, JE ;
FISHELL, E ;
SIMOR, I ;
COOKE, G ;
GERMANSON, T .
BRITISH JOURNAL OF CANCER, 1982, 45 (02) :185-193
[8]  
BOYD NF, IN PRESS CANC EPIDEM
[9]   DIET, MAMMOGRAPHIC FEATURES OF BREAST-TISSUE, AND BREAST-CANCER RISK [J].
BRISSON, J ;
VERREAULT, R ;
MORRISON, AS ;
TENNINA, S ;
MEYER, F .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1989, 130 (01) :14-24
[10]   MAMMOGRAPHIC FEATURES OF THE BREAST AND BREAST-CANCER RISK [J].
BRISSON, J ;
MERLETTI, F ;
SADOWSKY, NL ;
TWADDLE, JA ;
MORRISON, AS ;
COLE, P .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1982, 115 (03) :428-437