Pathophysiology of Erectile Dysfunction

被引：68
作者：
Matsui, Hotaka
Sopko, Nikolai A.
Hannan, Johanna L.
Bivalacqua, Trinity J.
机构：
[1] Johns Hopkins Sch Med, James Buchanan Brady Urol Inst, Baltimore, MD USA
[2] Johns Hopkins Sch Med, Dept Urol, Baltimore, MD USA
来源：
CURRENT DRUG TARGETS | 2015年 / 16卷 / 05期
基金：
英国医学研究理事会;
关键词：
Angiotensin; erectile dysfunction; nitric oxide; pathophysiology; reactive oxygen species; RhoA/Rho-associated protein kinase; tumor necrosis factor-alpha; NITRIC-OXIDE SYNTHASE; MAJOR PELVIC GANGLION; CAVERNOUS NERVE INJURY; BLADDER OUTLET OBSTRUCTION; URINARY-TRACT SYMPTOMS; VIVO GENE-THERAPY; SEXUAL DYSFUNCTION; CORPUS CAVERNOSUM; ENDOTHELIAL DYSFUNCTION; SMOOTH-MUSCLE;
D O I：
10.2174/138945011605150504114041
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Erectile dysfunction (ED) is a major health problem as the population ages. Basic science research for the last two decades has expanded the knowledge on ED and identified several key molecular changes associated with the pathogenesis of ED, including nitric oxide (NO)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) pathway, RhoA/Rho-associated protein kinase (ROCK) signaling pathway, reactive oxygen species (ROS), renin-angiotensin system (RAS) and tumor necrosis factor-alpha (TNF-alpha). The causes of ED are classified into aging, vasculogenic, neurogenic, endocrinological, drug-induced and psychogenic. ED is often associated with systemic diseases, such as diabetes and cardiovascular diseases. In this review, we will review the molecular mechanisms of ED and known mechanisms behind ED associated with systemic diseases.
引用
收藏
页码：411 / 419
页数：9
相关论文
共 151 条
[1]   Role of oxidative stress in the pathophysiological mechanism of erectile dysfunction [J].
Agarwal, A ;
Nandipati, KC ;
Sharma, RK ;
Zippe, CD ;
Raina, R .
JOURNAL OF ANDROLOGY, 2006, 27 (03) :335-347
[2]  
AIZENBERG D, 1995, J CLIN PSYCHIAT, V56, P137
[3]   Expression of a Distinct Set of Chemokine Receptors in Adipose Tissue-Derived Stem Cells is Responsible for In Vitro Migration Toward Chemokines Appearing in the Major Pelvic Ganglion Following Cavernous Nerve Injury [J].
Albersen, Maarten ;
Berkers, Joost ;
Dekoninck, Philip ;
Deprest, Jan ;
Lue, Tom F. ;
Hedlund, Petter ;
Lin, Ching-Shwun ;
Bivalacqua, Trinity J. ;
Van Poppel, Hendrik ;
De Ridder, Dirk ;
Van der Aa, Frank .
SEXUAL MEDICINE, 2013, 1 (01) :3-15
[4]   Smoking as a risk factor for erectile dysfunction: Data from the Andrology Prevention Weeks 2001-2002 a study of the Italian Society of Andrology (SIA) [J].
Austoni, E ;
Mirone, V ;
Parazzini, F ;
Fasolo, CB ;
Turchi, P ;
Pescatori, ES ;
Ricci, E ;
Gentile, V .
EUROPEAN UROLOGY, 2005, 48 (05) :810-818
[5]  
Aytac IA, 1999, BJU INT, V84, P50
[6]   Vasculogenic erectile dysfunction: Beyond the haemodynamic changes [J].
Azadzoi, KM .
BJU INTERNATIONAL, 2006, 97 (01) :11-16
[7]   Erectile dysfunction as a harbinger for increased cardiometabolic risk [J].
Billups, K. L. ;
Bank, A. J. ;
Padma-Nathan, H. ;
Katz, S. D. ;
Williams, R. A. .
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, 2008, 20 (03) :236-242
[8]   Erectile dysfunction is a marker for cardiovascular disease: Results of the minority health institute expert advisory panel [J].
Billups, KL ;
Bank, AJ ;
Padma-Nathan, H ;
Katz, S ;
Williams, R .
JOURNAL OF SEXUAL MEDICINE, 2005, 2 (01) :40-50
[9]   Increased expression of arginase II in human diabetic corpus cavernosum: In diabetic-associated erectile dysfunction [J].
Bivalacqua, TJ ;
Hellstrom, WJG ;
Kadowitz, PJ ;
Champion, HC .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 283 (04) :923-927
[10]   Superoxide anion production in the rat penis impairs erectile function in diabetes: Influence of in vivo extracellular superoxide dismutase gene therapy [J].
Bivalacqua, TJ ;
Usta, MF ;
Kendirci, M ;
Pradhan, L ;
Alvarez, X ;
Champion, HC ;
Kadowitz, PJ ;
Hellstrom, WJG .
JOURNAL OF SEXUAL MEDICINE, 2005, 2 (02) :187-197
12345678910