Efficacy and Tolerability of Antidepressants in the Treatment of Behavioral and Psychological Symptoms of Dementia, A Literature Review of Evidence

被引：56

作者：

Henry, Genevieve ^{[1
]}

Williamson, Deena ^{[2
]}

Tampi, Rajesh R. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA

[2] Masonicare, Wallingford, CT USA

来源：

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2011年 / 26卷 / 03期

关键词：

dementia; behavioral and psychological symptoms of dementia; antidepressants; selective serotonin reuptake inhibitors; trazodone; RANDOMIZED-CONTROLLED-TRIAL; CONTROLLED CLINICAL-TRIAL; ALZHEIMERS-DISEASE; FRONTOTEMPORAL DEMENTIA; DOUBLE-BLIND; NEUROPSYCHIATRIC SYMPTOMS; PSYCHOTIC SYMPTOMS; DISTURBANCES; SERTRALINE; PLACEBO;

D O I：

10.1177/1533317511402051

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The objective of this review is to summarize the current data on the use of antidepressants in the treatment of behavioral and psychological symptoms of dementia (BPSD) and to determine whether these medications can be recommended for routine clinical use. A literature search of six major databases (PubMed, Medline, PsychINFO, Scopus, Web of Science and Cochrane collaboration) trials, 8 using a selective serotonin reuptake inhibitor (SSRI) compound and 3 using trazodone showed benefit in the treatment of BPSD. The antidepressant drug was well tolerated in at least 14 of the 19 trials with information about tolerability in one trial not provided in the study (paroxetine or placebo for FTD). This review indicates that antidepressants can be an effective in the treatment of BPSD and are generally well tolerated in elderly demented patients.

引用

页码：169 / 183

页数：15

共 36 条

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