Antimicrobial Isopropenyl-dihydrofuranoisoflavones from Crotalaria lachnophora

被引：51

作者：

Awouafack, Maurice Ducret ^{[1
,2
]}

Spiteller, Peter ^{[3
]}

Lamshoeft, Marc ^{[2
]}

Kusari, Souvik ^{[2
]}

Ivanova, Bojidarka ^{[2
]}

Tane, Pierre ^{[1
]}

Spiteller, Michael ^{[2
]}

机构：

[1] Univ Dschang, Dept Chem, Lab Nat Prod Chem, Dschang, Cameroon

[2] Tech Univ Dortmund, Lehrstuhl Umweltchem & Analyt Chem, Fak Chem, Inst Umweltforsch INFU, D-44221 Dortmund, Germany

[3] Univ Freiburg, Inst Organ Chem & Biochem, D-79104 Freiburg, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 02期

关键词：

PYRROLIZIDINE ALKALOIDS; ABSOLUTE-CONFIGURATIONS; OPTICAL-ROTATION; NATURAL-PRODUCTS; CAJANUS-CAJAN; FLAVONOIDS; CONSTITUENTS; SEEDS;

D O I：

10.1021/np1005218

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new isopropenyl-dihydrofuranoisoflavones exhibiting antimicrobial properties have been isolated along with eight known compounds from the Cameroonian medicinal plant Crotalaria lachnophora. The Structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and high-resolution mass spectrometry as 7,2',4'-trihydroxy-5 ''-isopropenyl-4 '',5 ''-dihydrofurano[2 '',3 '':5,6]isoflavone (1) and 4,8-dihydroxy-2-isopropenyl-2,3-dihydro-5H-[1]benzofuro-[2,3-b]furo[3,2-g] chromen-5-one (2). The CH2Cl2/MeOH (1:1) extract and the compounds isolated were subjected to in vitro antimicrobial assays against a panel of pathogenic Microorganisms, including Gram-Positive and Gram-negative bacteria and fungi. The new compounds, named lachnoisoflavones A (1) and B (2), showed moderate inhibitory activities against Escherichia coli and Klebsielia pneumoniae.

引用

页码：272 / 278

页数：7

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