Kinetic resolution of 1,2-diols through highly site- and enantioselective catalytic silylation

被引：106

作者：

Zhao, Yu ^{[1
]}

Mitra, Aurpon W. ^{[1
]}

Hoveyda, Amir H. ^{[1
]}

Snapper, Marc L. ^{[1
]}

机构：

[1] Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 44期

关键词：

asymmetric catalysis; diols; enantioselective synthesis; kinetic resolution; silylation;

D O I：

10.1002/anie.200703650

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Resolved to silylate: A chiral silylation catalyst is used for kinetic resolution of three classes of acyclic 1,2-diols. The catalyst differentiates, with excellent precision, between the two hydroxy groups of a substrate. The majority of the diols, obtained in high enantiomeric purity, cannot be accessed with similar stereochemical purity through catalytic asymmetric dihydroxylation. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8471 / 8474

页数：4

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