Kinetic resolution of 1,2-diols through highly site- and enantioselective catalytic silylation

被引：103
|
作者：
Zhao, Yu [1 ]
Mitra, Aurpon W. [1 ]
Hoveyda, Amir H. [1 ]
Snapper, Marc L. [1 ]
机构：
[1] Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 44期
关键词：
asymmetric catalysis; diols; enantioselective synthesis; kinetic resolution; silylation;
D O I：
10.1002/anie.200703650
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Resolved to silylate: A chiral silylation catalyst is used for kinetic resolution of three classes of acyclic 1,2-diols. The catalyst differentiates, with excellent precision, between the two hydroxy groups of a substrate. The majority of the diols, obtained in high enantiomeric purity, cannot be accessed with similar stereochemical purity through catalytic asymmetric dihydroxylation. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：8471 / 8474
页数：4
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