Development of gut-homing receptors on circulating B cells during infancy

被引：18

作者：

Lundell, Anna-Carin ^{[1
]}

Rabe, Hardis ^{[1
]}

Quiding-Jarbrink, Marianne ^{[2
,3
]}

Andersson, Kerstin ^{[1
]}

Nordstrom, Inger ^{[1
]}

Adlerberth, Ingegerd ^{[4
]}

Wold, Agnes E. ^{[4
]}

Rudin, Anna ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, S-40530 Gothenburg, Sweden

[2] Univ Gothenburg, Sahlgrenska Acad, Dept Microbiol & Immunol, S-40530 Gothenburg, Sweden

[3] Univ Gothenburg, Sahlgrenska Acad, Vaccine Res Inst, S-40530 Gothenburg, Sweden

[4] Univ Gothenburg, Sahlgrenska Acad, Dept Clin Bacteriol, S-40530 Gothenburg, Sweden

来源：

CLINICAL IMMUNOLOGY | 2011年 / 138卷 / 01期

基金：

瑞典研究理事会;

关键词：

Infants; B cells; Gut-homing receptors; PLASMA-CELLS; T-CELLS; VASCULAR ADDRESSIN; CUTTING EDGE; L-SELECTIN; BETA; 7; MUCOSAL; IGA; EXPRESSION; TISSUE;

D O I：

10.1016/j.clim.2010.10.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cell gut-homing is mainly mediated by alpha 4 beta 7, CCR9 and CCR10. We here studied the expression of these receptors on B cells from cord blood and from peripheral blood at 1, 4, 18 and 36 months of age in a prospective cohort of Swedish infants. The proportion of all B cells expressing alpha 4 beta 7 as well as the fraction of CCR10+ B cells expressing alpha 4 beta 7 was highest in early infancy. Nearly all naive B cells in all age groups expressed alpha 4 beta 7, whereas the expression on class-switched B cells decreased with age. Moreover, the proportion of both IgA+ and IgG+ B cells expressing alpha 4 beta 7, CCR9 and CCR10 were higher during the first months when compared to adults. In conclusion, the high fraction of circulating IgA+ and IgG+ B cells expressing CCR9 and CCR10 in the first months of life indicates activation of naive B cells in the gut, coinciding with bacterial colonization. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：97 / 106

页数：10

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