The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1

被引：145

作者：

Galande, Sanjeev ^{[1
]}

Purbey, Prabhat Kumar ^{[1
]}

Notani, Dimple ^{[1
]}

Kumar, P. Pavan ^{[1
]}

机构：

[1] Natl Ctr Cell Sci, Pune 411007, Maharashtra, India

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2007年 / 17卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.gde.2007.08.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Compartmentalized distribution of functional components is a hallmark of the eukaryotic nucleus. Technological advances in recent years have provided unprecedented insights into the role of chromatin organization and interactions of various structural-functional components toward gene regulation. SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation. Studies in recent years have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of IFN gamma treatment on chromatin loop architecture of the MHC class-I locus and altered expression of genes within the locus. At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin.

引用

页码：408 / 414

页数：7

共 26 条

[1] Chromatin domains and the interchromatin compartment form structurally defined and functionally interacting nuclear networks [J].