Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives

被引:122
作者
Anastasiu, Costin Vlad [1 ]
Moga, Marius Alexandru [1 ]
Elena Neculau, Andrea [2 ]
Balan, Andreea [1 ]
Scarneciu, Ioan [1 ]
Dragomir, Roxana Maria [1 ]
Dull, Ana-Maria [3 ]
Chicea, Liana-Maria [4 ]
机构
[1] Transilvania Univ Brasov, Dept Med & Surg Specialties, Fac Med, Brasov 500019, Romania
[2] Univ Transilvania Brasov, Fac Med, Dept Fundamental Prophylact & Clin Sci, Brasov 500019, Romania
[3] Regina Maria Hosp, Brasov 500091, Romania
[4] Univ Lucian Blaga Sibiu, Victor Papilian Med Sch, Sibiu 550024, Romania
关键词
biomarker; angiogenesis; cytokines; urinary biomarkers; endometriosis; FACTOR-KAPPA-B; INTERCELLULAR-ADHESION MOLECULE-1; PERITONEAL-FLUID; OXIDATIVE STRESS; PERIPHERAL-BLOOD; GROWTH-FACTOR; POTENTIAL BIOMARKERS; BINDING PROTEIN-3; INHIBITORY FACTOR; SERUM BIOMARKERS;
D O I
10.3390/ijms21051750
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Early and accurate diagnosis of endometriosis is crucial for the management of this benign, yet debilitating pathology. Despite the advances of modern medicine, there is no common ground regarding the pathophysiology of this disease as it continues to affect the quality of life of millions of women of reproductive age. The lack of specific symptoms often determines a belated diagnosis. The gold standard remains invasive, surgery followed by a histopathological exam. A biomarker or a panel of biomarkers is easy to measure, usually noninvasive, and could benefit the clinician in both diagnosing and monitoring the treatment response. Several studies have advanced the idea of biomarkers for endometriosis, thereby circumventing unnecessary invasive techniques. Our paper aims at harmonizing the results of these studies in the search of promising perspectives on early diagnosis. Methods: We selected the papers from Google Academic, PubMed, and CrossRef and reviewed recent articles from the literature, aiming to evaluate the effectiveness of various putative serum and urinary biomarkers for endometriosis. Results: The majority of studies focused on a panel of biomarkers, rather than a single biomarker and were unable to identify a single biomolecule or a panel of biomarkers with sufficient specificity and sensitivity in endometriosis. Conclusion: Noninvasive biomarkers, proteomics, genomics, and miRNA microarray may aid the diagnosis, but further research on larger datasets along with a better understanding of the pathophysiologic mechanisms are needed.
引用
收藏
页数:24
相关论文
共 152 条
[1]   The role of free radicals and antioxidants in reproduction [J].
Agarwal, A ;
Gupta, S ;
Sikka, S .
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 2006, 18 (03) :325-332
[2]   Clinical diagnosis of endometriosis: a call to action [J].
Agarwal, Sanjay K. ;
Chapron, Charles ;
Giudice, Linda C. ;
Laufer, Marc R. ;
Leyland, Nicholas ;
Missmer, Stacey A. ;
Singh, Sukhbir S. ;
Taylor, Hugh S. .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2019, 220 (04) :354.e1-354.e12
[3]   Combination of CCR1 mRNA, MCP1, and CA125 Measurements in Peripheral Blood as a Diagnostic Test for Endometriosis [J].
Agic, Admir ;
Djalali, Schima ;
Wolfler, Monika M. ;
Halis, Gulden ;
Diedrich, Klaus ;
Hornung, Daniela .
REPRODUCTIVE SCIENCES, 2008, 15 (09) :906-911
[4]   Biomarkers in endometriosis: challenges and opportunities [J].
Ahn, Soo Hyun ;
Singh, Vinay ;
Tayade, Chandrakant .
FERTILITY AND STERILITY, 2017, 107 (03) :523-532
[5]   IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors [J].
Ahn, Soo Hyun ;
Edwards, Andrew K. ;
Singh, Sukhbir S. ;
Young, Steven L. ;
Lessey, Bruce A. ;
Tayade, Chandrakant .
JOURNAL OF IMMUNOLOGY, 2015, 195 (06) :2591-2600
[6]   Increased oxidation-related glutathionylation and carbonic anhydrase activity in endometriosis [J].
Andrisani, Alessandra ;
Dona, Gabriella ;
Brunati, Anna Maria ;
Clari, Giulio ;
Armanini, Decio ;
Ragazzi, Eugenio ;
Ambrosini, Guido ;
Bordin, Luciana .
REPRODUCTIVE BIOMEDICINE ONLINE, 2014, 28 (06) :773-779
[7]   Endometriosis: The Role of Neuroangiogenesis [J].
Asante, Albert ;
Taylor, Robert N. .
ANNUAL REVIEW OF PHYSIOLOGY, VOL 73, 2011, 73 :163-182
[8]   Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].
Atkinson, AJ ;
Colburn, WA ;
DeGruttola, VG ;
DeMets, DL ;
Downing, GJ ;
Hoth, DF ;
Oates, JA ;
Peck, CC ;
Schooley, RT ;
Spilker, BA ;
Woodcock, J ;
Zeger, SL .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95
[9]   Cyclooxygnemase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms [J].
Banu, S. K. ;
Lee, J. ;
Speights, V. O., Jr. ;
Starzinski-Powitz, A. ;
Arosh, J. A. .
ENDOCRINOLOGY, 2008, 149 (03) :1180-1189
[10]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29